Myeloid Progenitor Inhibitory Factor 2 (MPIF2)

CCL24; SCYA24; Ckb-6; Eotaxin-2; Chemokine C-C-Motif Ligand 24; Eosinophil chemotactic protein 2; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 24

SPN	W117
HGNC	10623
MGI	1928953
PubMed	11237428
RGD	1310245
UniProt	O00175
Wiki	CCL24

Eotaxin-2 is constitutively expressed in the jejunum and spleen. It can also be induced in the lung by allergen challenge and Il-4. LPS and IL-4 also differentially regulate the expression of eotaxin-2 in monocytes and macrophages. Mouse eotaxin-2 cDNA encodes a 119 amino acid (aa) residue precursor protein that shares approximately 58% aa sequence identity with human eotaxin-2. Functionally, eotaxin-2 is most closely related to eotaxin/CCL11 and eotaxin-3/CCL26. The three proteins share low sequence homology but have been shown to be potent eosinophil chemoattractants that bind and activate the chemokine receptor CCR3, a receptor that is highly expressed in eosinophils. Eotaxin-2 also has the ability to suppress myeloid cell proliferation, a biological function not shared by eotaxin.

Reference

"Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors."
J. Exp. Med. 185:1163-1172(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils."
J. Leukoc. Biol. 62:667-675(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2."
Biochemistry 39:8382-8395(2000) [PubMed] [Europe PMC] [Abstract]