Kallikrein 10 (KLK10)

NES1; PRSSL1; Kallikrein-Related Peptidase 10; Normal epithelial cell-specific 1; Protease serine-like 1

SPN	W115
HGNC	6358
MGI	1916790
PubMed	12821340
RGD	1303242
UniProt	O43240
Wiki	KLK10

KLK10 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.

The deduced 276-amino acid protein contains a putative signal peptide, followed by a short activating peptide and the protease domain, which includes the catalytic triad of his86, asp137, and ser229. KLK10 also contains 12 conserved cysteines in its protease domain that are expected to form 6 disulfide bonds, as in other serine proteases. RT-PCR detected variable levels of KLK10 expression in nearly all of the 35 adult and fetal tissues examined.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	W115Hu01	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	MW115Hu22	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	PW115Hu01	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	LW115Hu71	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	PW115Mu01	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	PW115Ra01	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Kallikrein 10 (KLK10)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Kallikrein 10 (KLK10)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Kallikrein 10 (KLK10)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Kallikrein 10 (KLK10)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Kallikrein 10 (KLK10)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Kallikrein 10 (KLK10)	CLIA assay for Antigen Detection

Reference

"Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression."
Cancer Res. 56:3371-3379(1996) [PubMed] [Europe PMC] [Abstract]

"Structural characterization and mapping of the normal epithelial cell-specific 1 gene."
Biochem. Biophys. Res. Commun. 247:580-586(1998) [PubMed] [Europe PMC] [Abstract]

"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker."
Tumor Biol. 26:227-235(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The role for NES1 serine protease as a novel tumor suppressor."
Cancer Res. 58:4782-4786(1998) [PubMed] [Europe PMC] [Abstract]