Mucin 2 (MUC2)
MLP; SMUC; Oligomeric Mucus/Gel-Forming; Mucin 2,Intestinal/Tracheal
Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side chains which are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.
The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Hu01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Hu01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Hu01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Hu01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Hu01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Mu01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Mu01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Mu01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Mu01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Mu01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Ra01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Ra01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Ra01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Ra01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Ra01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Ca01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Ca01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Ca01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Ca01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Ca01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Po01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Po01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Po01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Po01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Po01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Bo01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Bo01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Bo01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Bo01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Bo01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Rb01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Rb01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Rb01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Rb01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Rb01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW107Mo01 | Recombinant Mucin 2 (MUC2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW107Mo01 | Monoclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IP. |
| PAW107Mo01 | Polyclonal Antibody to Mucin 2 (MUC2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW107Mo01 | CLIA Kit for Mucin 2 (MUC2) | CLIA assay for Antigen Detection |
| ELW107Mo01 | ELISA Kit for Mucin 2 (MUC2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor."
J. Biol. Chem. 269:2440-2446(1994) [PubMed] [Europe PMC] [Abstract]
"The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region."
J. Biol. Chem. 267:21375-21383(1992) [PubMed] [Europe PMC] [Abstract]
"MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism."
J. Clin. Invest. 88:1005-1013(1991) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism."
J. Biol. Chem. 264:6480-6487(1989) [PubMed] [Europe PMC] [Abstract]
"Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5."
Biochem. Biophys. Res. Commun. 183:821-828(1992) [PubMed] [Europe PMC] [Abstract]
"In vivo glycosylation of mucin tandem repeats."
Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
"The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment."
J. Biol. Chem. 277:47248-47256(2002) [PubMed] [Europe PMC] [Abstract]
"An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway."
J. Biol. Chem. 278:13944-13951(2003) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."
Proc. Natl. Acad. Sci. U.S.A. 106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]
"Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."
J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]