CCAAT/Enhancer Binding Protein Beta (CEBPb)

CRP2; IL6DBP; LAP; NF-IL6; TCF5; C/EBP-Beta; Liver-Enriched Transcriptional Activator Protein; Nuclear Factor Of Interleukin 6; Interleukin 6-Dependent DNA-Binding Protein

SPN	W099
HGNC	1834
MGI	88373
PubMed	16418324
RGD	2327
UniProt	P17676
Wiki	CEBPB

CCAAT/enhancer-binding protein beta is aencoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma.

CEBPbis important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.

Reference

"A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family."
EMBO J. 9:1897-1906(1990) [PubMed] [Europe PMC] [Abstract]

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family."
Eur. J. Biochem. 231:292-299(1995) [PubMed] [Europe PMC] [Abstract]

"Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299."
J. Biol. Chem. 272:30356-30361(1997) [PubMed] [Europe PMC] [Abstract]

"C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival."
Mol. Cell 8:807-816(2001) [PubMed] [Europe PMC] [Abstract]

"Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins."
J. Biol. Chem. 277:6923-6928(2002) [PubMed] [Europe PMC] [Abstract]

"MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma."
Proc. Natl. Acad. Sci. U.S.A. 99:7945-7950(2002) [PubMed] [Europe PMC] [Abstract]

"Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3."
J. Biol. Chem. 278:33416-33421(2003) [PubMed] [Europe PMC] [Abstract]

"Nine-amino-acid transactivation domain: establishment and prediction utilities."
Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]

"G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta."
J. Biol. Chem. 283:26357-26363(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."
EMBO J. 29:1105-1115(2010) [PubMed] [Europe PMC] [Abstract]

"Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."
J. Biol. Chem. 285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]

"Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) beta."
J. Biol. Chem. 290:755-761(2015) [PubMed] [Europe PMC] [Abstract]

"Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta."
Cell 104:755-767(2001) [PubMed] [Europe PMC] [Abstract]

"Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter."
Cell 108:57-70(2002) [PubMed] [Europe PMC] [Abstract]