ADP Ribosyltransferase 4 (ART4)

CD297; DO; DOK1; Dombrock blood group carrier molecule; Ecto-ADP-ribosyltransferase 4; ADP-ribosyltransferase C2 and C3 toxin-like 4; Mono(ADP-ribosyl)transferase 4

SPN	W093
HGNC	726
MGI	1202710
PubMed	11879200
RGD	1306456
UniProt	Q93070
Wiki	ART4

Ecto-ADP-ribosyltransferase 4 is a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.The ART4 gene encodes a predicted 314-amino acid polypeptide containing an arginine-glycine-aspartic acid (RGD) motif, commonly involved in cell-to-cell interactions involving integrin binding and the GPI anchor motif. Gubin et al. stated that although the identity of DO to ART4 had been established, enzymatic activity has not been demonstrated in any cell type, including erythroid cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Hu01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Hu01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Hu01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Hu01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Hu01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Mu01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Mu01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Mu01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Mu01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Mu01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Ra01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Ra01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Ra01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Ra01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Ra01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Ca01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Ca01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Ca01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Ca01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Ca01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Po01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Po01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Po01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Po01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Po01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Bo01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Bo01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Bo01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Bo01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Bo01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Rb01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Rb01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Rb01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Rb01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Rb01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW093Mo01	Recombinant ADP Ribosyltransferase 4 (ART4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW093Mo01	Monoclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IP.
Antibodies	PAW093Mo01	Polyclonal Antibody to ADP Ribosyltransferase 4 (ART4)	WB; IHC; ICC; IF.
Assay Kits	CLW093Mo01	CLIA Kit for ADP Ribosyltransferase 4 (ART4)	CLIA assay for Antigen Detection
Assay Kits	ELW093Mo01	ELISA Kit for ADP Ribosyltransferase 4 (ART4)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family."
Blood 96:2621-2627(2000) [PubMed] [Europe PMC] [Abstract]

"Insights into the Holley- and Joseph- phenotypes."
Transfusion 42:52-58(2002) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins."
Genomics 39:370-376(1997) [PubMed] [Europe PMC] [Abstract]

"Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors."
Vox Sang. 81:49-51(2001) [PubMed] [Europe PMC] [Abstract]

"Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]