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Complement Component 7 (C7)

  • C7 is a single-chain plasma glycoprotein involved in the cytolytic phase of complement activation (Hobart et al., 1995). Mutations in the C7 gene cause C7 deficiency, a defect associated with increased susceptibility to neisserial recurrent infections (Barroso et al., 2004). Hobart et al. (1978) identified 3 structural forms of C7, concluded they are the products of 3 codominant alleles at an autosomal locus, and found that the C6 and C7 loci are closely linked to each other but not to the HLA complex. By Southern blot analysis of hybrid cell DNAs using cDNA probes, Jeremiah et al. demonstrated that the human C6 and C7 genes are located on chromosome 5. See Coto et al. (1991) for linkage information indicating that C6, C7, and C9 are closely situated; C9 was mapped to 5p13.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Hu01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Hu01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Hu01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Hu01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Hu01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Mu01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Mu01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Mu01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Mu01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Mu01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Ra01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Ra01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Ra01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Ra01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Ra01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Ca01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Ca01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Ca01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Ca01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Ca01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Po01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Po01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Po01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Po01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Po01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Bo01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Bo01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Bo01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Bo01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Bo01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Rb01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Rb01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Rb01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Rb01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Rb01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW081Mo01 Recombinant Complement Component 7 (C7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW081Mo01 Monoclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IP.
PAW081Mo01 Polyclonal Antibody to Complement Component 7 (C7) WB; IHC; ICC; IF.
Assay Kits CLW081Mo01 CLIA Kit for Complement Component 7 (C7) CLIA assay for Antigen Detection
ELW081Mo01 ELISA Kit for Complement Component 7 (C7) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The structure of human complement component C7 and the C5b-7 complex."
J. Biol. Chem. 263:549-560(1988) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the human C7 gene and comparison with the C6, C8A, C8B and C9 genes."
J. Immunol. 154:5188-5194(1995) [PubMed] [Europe PMC] [Abstract]

"The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
J. Biol. Chem. 274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

"Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement."
J. Biol. Chem. 284:19637-19649(2009) [PubMed] [Europe PMC] [Abstract]

"Molecular bases of combined subtotal deficiencies of C6 and C7: their effects in combination with other C6 and C7 deficiencies."
J. Immunol. 157:3648-3657(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular bases of C7 deficiency: three different defects."
J. Immunol. 159:1019-1026(1997) [PubMed] [Europe PMC] [Abstract]

"Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes."
Hum. Genet. 103:513-519(1998) [PubMed] [Europe PMC] [Abstract]

"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]