Protein Z (PROZ)

PRO-Z; PZ; Vitamin K Dependent Protein Z; VKDPZ; VKDP-Z

SPN	W076
HGNC	9460
MGI	1860488
PubMed	15841316
RGD	1308666
UniProt	P22891
Wiki	Protein_Z

Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Structural analysis of protein Z will allow better understanding of its function. From a Ramachandran plot, the secondary structure of Protein Z was determined. The Ramachandran plot utilizes mathematical equations to determine the possible angles of the amino acids within the primary sequence of Protein Z. The possible angles results in a plot of possible secondary structures. The Ramachandran plot for protein Z indicates it will form alpha helices. The final structure, all aphla domain, was determined by x-ray diffraction. It consists of chain A and B, which are both helix-loop-helix motifs.

Reference

"Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein."
Biochem. Biophys. Res. Commun. 172:1139-1144(1990) [PubMed] [Europe PMC] [Abstract]

"The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon."
Biochemistry 37:6838-6846(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Primary structure of vitamin K-dependent human protein Z."
Biochem. Biophys. Res. Commun. 171:661-668(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z."
J. Biol. Chem. 264:20320-20325(1989) [PubMed] [Europe PMC] [Abstract]

"A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z."
Adv. Exp. Med. Biol. 281:121-131(1990) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X."
Blood 114:3662-3667(2009) [PubMed] [Europe PMC] [Abstract]

"Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa."
J. Biol. Chem. 285:20399-20409(2010) [PubMed] [Europe PMC] [Abstract]