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Complement Receptor 2 (CR2)

CD21; C3DR; Complement Component(3d/Epstein Barr Virus)Receptor 2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor

CR2 and CD21, is a protein involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d.B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation .CR2 on mature B cells form a complex with two other membrane proteins, CD19 and CD81(=TAPA-1). The CR2-CD19-CD81 complex is often called the B cell coreceptor complex,[3] because CR2 binds to antigens through attached C3d (or iC3b or C3dg) when the menbrane IgM binds to the antigen. This results in the B cell to have greatly enhanced response to the antigen.Epstein-Barr virus (EBV) binds to B cells at CR2 during infection of these cells. Yefenof et al. (1976) found complete overlapping of EBV receptors and C3 receptors on human B lymphocytes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Hu01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Hu01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Hu01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Hu01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Hu01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Mu01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Mu01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Mu01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Mu01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Mu01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Ra01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Ra01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Ra01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Ra01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Ra01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Ca01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Ca01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Ca01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Ca01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Ca01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Po01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Po01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Po01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Po01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Po01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Bo01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Bo01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Bo01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Bo01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Bo01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Rb01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Rb01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Rb01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Rb01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Rb01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW062Mo01 Recombinant Complement Receptor 2 (CR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW062Mo01 Monoclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IP.
PAW062Mo01 Polyclonal Antibody to Complement Receptor 2 (CR2) WB; IHC; ICC; IF.
Assay Kits CLW062Mo01 CLIA Kit for Complement Receptor 2 (CR2) CLIA assay for Antigen Detection
ELW062Mo01 ELISA Kit for Complement Receptor 2 (CR2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor."
J. Biol. Chem. 264:2118-2125(1989) [PubMed] [Europe PMC] [Abstract]

"Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins."
J. Exp. Med. 167:1047-1066(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the cDNA encoding the Epstein-Barr virus.C3d receptor (complement receptor type 2) of human b lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 84:9194-9198(1987) [PubMed] [Europe PMC] [Abstract]

"Evidence for a new transcript of the Epstein-Barr virus/C3d receptor (CR2, CD21) which is due to alternative exon usage."
Mol. Immunol. 35:1025-1031(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement."
Proc. Natl. Acad. Sci. U.S.A. 83:5639-5643(1986) [PubMed] [Europe PMC] [Abstract]

"Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript."
J. Immunol. 150:5311-5320(1993) [PubMed] [Europe PMC] [Abstract]

"Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein."
Mol. Immunol. 32:389-397(1995) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Genetic CD21 deficiency is associated with hypogammaglobulinemia."
J. Allergy Clin. Immunol. 129:801-810(2012) [PubMed] [Europe PMC] [Abstract]

"Structure of complement receptor 2 in complex with its C3d ligand."
Science 292:1725-1728(2001) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding."
Proc. Natl. Acad. Sci. U.S.A. 99:10641-10646(2002) [PubMed] [Europe PMC] [Abstract]

"The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions."
J. Mol. Biol. 362:1132-1147(2006) [PubMed] [Europe PMC] [Abstract]

"A crystal structure of the complex between human complement receptor 2 and its ligand C3d."
Science 332:608-611(2011) [PubMed] [Europe PMC] [Abstract]

"Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus."
Proc. Natl. Acad. Sci. U.S.A. 104:3961-3966(2007) [PubMed] [Europe PMC] [Abstract]