Programmed Cell Death Protein 1 (PDCD1)
CD279; PD1; SLEB2; HPD1
Programmed cell death 1, also known as PDCD1, is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation.
In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.
These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Hu01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Hu01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Hu01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Hu01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Hu01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Mu01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Mu01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Mu01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Mu01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Mu01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Ra01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Ra01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Ra01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Ra01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Ra01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Ca01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Ca01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Ca01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Ca01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Ca01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Po01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Po01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Po01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Po01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Po01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Bo01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Bo01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Bo01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Bo01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Bo01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Rb01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Rb01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Rb01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Rb01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Rb01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW061Mo01 | Recombinant Programmed Cell Death Protein 1 (PDCD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW061Mo01 | Monoclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IP. |
| PAW061Mo01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PDCD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW061Mo01 | CLIA Kit for Programmed Cell Death Protein 1 (PDCD1) | CLIA assay for Antigen Detection |
| ELW061Mo01 | ELISA Kit for Programmed Cell Death Protein 1 (PDCD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structure and chromosomal localization of the human PD-1 gene (PDCD1)."
Genomics 23:704-706(1994) [PubMed] [Europe PMC] [Abstract]
"The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors."
Gene 197:177-187(1997) [PubMed] [Europe PMC] [Abstract]
Erratum
Gene 203:253-253(1997)
"A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans."
Nat. Genet. 32:666-669(2002) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The role of the PD-1 pathway in autoimmunity and peripheral tolerance."
Ann. N. Y. Acad. Sci. 1217:45-59(2011) [PubMed] [Europe PMC] [Abstract]