Toll Like Receptor 4 (TLR4)
CD284; TOLL; HToll
TLR 4 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W059Hu01 | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | MW059Hu22 | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| PW059Hu01 | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| LW059Hu71 | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW059Hu | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W059Mu01 | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| PW059Mu01 | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| LW059Mu81 | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW059Mu | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCW059Mu | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W059Ra01 | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | MW059Ra21 | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| PW059Ra01 | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| LW059Ra71 | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| LW059Ra81 | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW059Ra | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | W059Bo01 | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | MW059Bo21 | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| PW059Bo01 | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEW059Bo | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Toll Like Receptor 4 (TLR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Toll Like Receptor 4 (TLR4) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Toll Like Receptor 4 (TLR4) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Toll Like Receptor 4 (TLR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Toll Like Receptor 4 (TLR4) | CLIA assay for Antigen Detection |
Reference
"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity."
Nature 388:394-397(1997) [PubMed] [Europe PMC] [Abstract]
"A family of human receptors structurally related to Drosophila Toll."
Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
"Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)."
Genome Biol. 1:RESEARCH002.1-RESEARCH002.10(2000) [PubMed] [Europe PMC] [Abstract]
"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans."
Nat. Genet. 25:187-191(2000) [PubMed] [Europe PMC] [Abstract]
"Natural selection in the TLR-related genes in the course of primate evolution."
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."
Nature 408:111-115(2000) [PubMed] [Europe PMC] [Abstract]
"MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor."
J. Biol. Chem. 277:1845-1854(2002) [PubMed] [Europe PMC] [Abstract]
"Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B."
J. Immunol. 173:3589-3593(2004) [PubMed] [Europe PMC] [Abstract]
"Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity."
Circ. Res. 100:1589-1596(2007) [PubMed] [Europe PMC] [Abstract]
"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Commun. 3:653-653(2012)
"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
"Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel."
Nat. Immunol. 11:814-819(2010) [PubMed] [Europe PMC] [Abstract]
"MLK4 has negative effect on TLR4 signaling."
Cell. Mol. Immunol. 9:27-33(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran."
Cell 130:906-917(2007) [PubMed] [Europe PMC] [Abstract]
"The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex."
Nature 458:1191-1195(2009) [PubMed] [Europe PMC] [Abstract]
"Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein."
PLoS ONE 7:E30929-E30929(2012) [PubMed] [Europe PMC] [Abstract]
"Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans."
Genetics 158:1657-1664(2001) [PubMed] [Europe PMC] [Abstract]
"Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration."
Hum. Mol. Genet. 14:1449-1455(2005) [PubMed] [Europe PMC] [Abstract]