Forkhead Box Protein M1 (FOXM1)

FKHL16; FOXM1B; HFH11; HNF3; INS1; MPHOSPH2; MPP2; PIG29; Trident; M-Phase Phosphoprotein 2; HNF-3/fork-head homolog 11; Winged-helix factor from INS-1 cells

SPN	W045
HGNC	3818
MGI	1347487
PubMed	19513552
RGD	61807
UniProt	Q08050
Wiki	FOXM1

Forkhead box protein M1 is a member of the FOX family of transcription factors.FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases.

FOXM1-null mouse embryos were neonatal lethal as a result of the development of polyploid cardiomyocytes and hepatocytes, highlighting the role of FOXM1 in mitotic division. More recently a study using transgenic/knockout mouse embryonic fibroblasts and human osteosarcoma cells (U2OS) has shown that FOXM1, regulates expression of a large array of G2/M-specific genes, such as Plk1, cyclin B2, Nek2 and CENPF, and plays an important role in maintenance of chromosomal segregation and genomic stability

Reference

"Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues."
Mol. Cell. Biol. 17:1626-1641(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain."
J. Biol. Chem. 272:19827-19836(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope."
Proc. Natl. Acad. Sci. U.S.A. 91:714-718(1994) [PubMed] [Europe PMC] [Abstract]

"Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."
Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]

"Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression."
Nat. Cell Biol. 10:1076-1082(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence."
Nucleic Acids Res. 38:4527-4538(2010) [PubMed] [Europe PMC] [Abstract]