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Lipase, Hepatic (LIPC)

HL; HTGL; Hepatic Lipase; Hepatic triacylglycerol lipase; Lipase member C

  • Hepatic lipase is a form of lipase. It is expressed in the liver and adrenal glands.One of the principal functions of hepatic lipase is to convert IDL to LDL.LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.

  • Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated high density lipoprotein (HDL) cholesterol due to a mutation in the hepatic lipase gene. Clinical features are not well understood and there are no characteristic xanthomas. There is an association with a delay in atherosclerosis in an animal model.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W043Hu01 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies MW043Hu22 Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
PW043Hu01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
LW043Hu71 Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits KEW043Hu ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins W043Mu01 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
PW043Mu01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
LW043Mu71 Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
LW043Mu81 FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits KEW043Mu ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
PW043Ra01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
LW043Ra71 Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
LW043Ra81 FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
PW043Po01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
LW043Po71 Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
LW043Po81 FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipase, Hepatic (LIPC) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipase, Hepatic (LIPC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipase, Hepatic (LIPC) CLIA assay for Antigen Detection

Reference

"Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line."
Differentiation 35:45-52(1987) [PubMed] [Europe PMC] [Abstract]

"Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase."
J. Biol. Chem. 263:1107-1110(1988) [PubMed] [Europe PMC] [Abstract]

"Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase."
J. Biol. Chem. 263:10907-10914(1988) [PubMed] [Europe PMC] [Abstract]

"Structure of the human hepatic triglyceride lipase gene."
Biochemistry 28:8966-8971(1989) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the human hepatic lipase gene."
J. Biol. Chem. 265:6552-6555(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"18 bp insertion/duplication with internal missense mutation in human hepatic lipase gene exon 3."
Hum. Mutat. 12:216-216(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene."
Mol. Cell. Probes 10:313-314(1996) [PubMed] [Europe PMC] [Abstract]

"The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish diabetes prevention study."
J. Clin. Endocrinol. Metab. 89:2019-2023(2004) [PubMed] [Europe PMC] [Abstract]

"The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects."
J. Clin. Endocrinol. Metab. 93:2294-2299(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human hepatic lipase mutations and polymorphisms."
Hum. Mutat. 1:320-324(1992) [PubMed] [Europe PMC] [Abstract]

"Genetic variants affecting human lipoprotein and hepatic lipases."
Curr. Opin. Lipidol. 2:104-109(1991)

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]