Inducible T-Cell Co Stimulator (ICOS)
CD278; AILIM; Inducible T-Cell Costimulator; Activation-Inducible Lymphocyte Immunomediatory Molecule
ICOS (Inducible T-cell COStimulator) is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for Th2 cells in particular.The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.Compared to wild-type naïve T cells, ICOS-/- T cells activated with plate-bound anti-CD3 have reduced proliferation and IL-2 secretion(1). The defect in proliferation can be rescued by addition of IL-2 to the culture, suggesting the proliferative defect is due to reduced IL-2 secretion. In terms of Th1 and Th2 cytokine secretion, ICOS-/- CD4+ T cell activated in vitro have reduced IL-4 secretion, but similar IFN-g secretion.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Hu01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Hu01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Hu01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Hu01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Hu01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Mu01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Mu01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Mu01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Mu01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Mu01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Ra01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Ra01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Ra01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Ra01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Ra01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Ca01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Ca01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Ca01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Ca01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Ca01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Po01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Po01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Po01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Po01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Po01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Bo01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Bo01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Bo01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Bo01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Bo01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Rb01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Rb01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Rb01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Rb01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Rb01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW035Mo01 | Recombinant Inducible T-Cell Co Stimulator (ICOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW035Mo01 | Monoclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IP. |
| PAW035Mo01 | Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW035Mo01 | CLIA Kit for Inducible T-Cell Co Stimulator (ICOS) | CLIA assay for Antigen Detection |
| ELW035Mo01 | ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28."
Nature 397:263-266(1999) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family."
Biochem. Biophys. Res. Commun. 276:335-345(2000) [PubMed] [Europe PMC] [Abstract]
"Characterization of human inducible costimulator ligand expression and function."
J. Immunol. 164:4689-4696(2000) [PubMed] [Europe PMC] [Abstract]
"Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."
Genomics 78:155-168(2001) [PubMed] [Europe PMC] [Abstract]
"Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation."
Tissue Antigens 61:276-285(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Induction, binding specificity and function of human ICOS."
Eur. J. Immunol. 30:3707-3717(2000) [PubMed] [Europe PMC] [Abstract]
"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency."
Nat. Immunol. 4:261-268(2003) [PubMed] [Europe PMC] [Abstract]