B-Cell Leukemia/Lymphoma 2 (Bcl2)

B-Cell CLL/Lymphoma 2

SPN	W034
HGNC	990
MGI	88138
PubMed	9735050
RGD	2199
UniProt	P10415
Wiki	Bcl-2

Bcl-2) was one of the first oncogenic proteins discovered to inhibit apoptosis. The Bcl-2 family of proteins plays a crucial role in the regulation of cell death in many eukaryotic systems. Bcl-2 is a 26 kD protein associated with cell survival.

Bcl-2 is localized within the outer mitochondrial membrane, endoplasmic reticulum, and the nuclear envelope, where it exerts cell survival functions within many cell types. These functions include ion-conducting channel formation, integral protection from cytotoxic agents, inhibition of proteins that activate caspases responsible for disassembling cells, as well as the ability to modulate cell cycle initiation.

Reference

"Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma."
Proc. Natl. Acad. Sci. U.S.A. 83:5214-5218(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo."
Nucleic Acids Res. 20:4187-4192(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation."
Cell 47:19-28(1986) [PubMed] [Europe PMC] [Abstract]

"Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma."
EMBO J. 7:123-131(1988) [PubMed] [Europe PMC] [Abstract]

"Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene."
Oncogene Res. 2:263-275(1988) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 18."
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas."
Blood 79:229-237(1992) [PubMed] [Europe PMC] [Abstract]

"Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death."
Nature 348:334-336(1990) [PubMed] [Europe PMC] [Abstract]

"BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax."
Nature 369:321-323(1994) [PubMed] [Europe PMC] [Abstract]

"BAG-1 modulates the chaperone activity of Hsp70/Hsc70."
EMBO J. 16:4887-4896(1997) [PubMed] [Europe PMC] [Abstract]

"Conversion of Bcl-2 to a Bax-like death effector by caspases."
Science 278:1966-1968(1997) [PubMed] [Europe PMC] [Abstract]

"The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M."
Mol. Cell. Biol. 16:3884-3892(1996) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of Bcl2 and regulation of apoptosis."
Leukemia 15:515-522(2001) [PubMed] [Europe PMC] [Abstract]

"BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M."
Mol. Cell. Biol. 19:8469-8478(1999) [PubMed] [Europe PMC] [Abstract]

"PUMA induces the rapid apoptosis of colorectal cancer cells."
Mol. Cell 7:673-682(2001) [PubMed] [Europe PMC] [Abstract]

"BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis."
Biochem. Biophys. Res. Commun. 308:379-385(2003) [PubMed] [Europe PMC] [Abstract]

"The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)."
FEBS Lett. 579:1469-1476(2005) [PubMed] [Europe PMC] [Abstract]

"p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association."
J. Biol. Chem. 280:24698-24705(2005) [PubMed] [Europe PMC] [Abstract]

"BMRP is a Bcl-2 binding protein that induces apoptosis."
J. Cell. Biochem. 94:611-626(2005) [PubMed] [Europe PMC] [Abstract]

"Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression."
J. Biol. Chem. 281:40493-40502(2006) [PubMed] [Europe PMC] [Abstract]

"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy."
Mol. Cell 30:678-688(2008) [PubMed] [Europe PMC] [Abstract]

"Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2."
Cancer Res. 69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract]

"Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect."
J. Biol. Chem. 284:9692-9699(2009) [PubMed] [Europe PMC] [Abstract]

"Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells."
Biochem. Biophys. Res. Commun. 401:231-237(2010) [PubMed] [Europe PMC] [Abstract]

"Parkin mono-ubiquitinates Bcl-2 and regulates autophagy."
J. Biol. Chem. 285:38214-38223(2010) [PubMed] [Europe PMC] [Abstract]

"Human Bop is a novel BH3-only member of the Bcl-2 protein family."
Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]

"Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma."
Proc. Natl. Acad. Sci. U.S.A. 110:3943-3948(2013) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the antiapoptotic protein bcl-2."
Proc. Natl. Acad. Sci. U.S.A. 98:3012-3017(2001) [PubMed] [Europe PMC] [Abstract]

"An inhibitor of Bcl-2 family proteins induces regression of solid tumours."
Nature 435:677-681(2005) [PubMed] [Europe PMC] [Abstract]

"Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL."
J. Med. Chem. 50:641-662(2007) [PubMed] [Europe PMC] [Abstract]