Cluster Of Differentiation 276 (CD276)

B7-H3; B7H3; CD276 Molecule; B7 homolog 3; Costimulatory molecule

SPN	W031
HGNC	19137
MGI	2183926
PubMed	24389327
RGD	727815
UniProt	Q5ZPR3
Wiki	CD276

• Sequence analysis predicted that the 316-amino acid type I transmembrane protein contains an N-terminal signal peptide; extracellular V- and C-like Ig domains with 4 conserved cysteine residues; a transmembrane region; and a 45-amino acid cytoplasmic tail. The extracellular receptor-binding domain of B7H3 shares 27% and 25% identity with those of B7H1 and B7H2, respectively. Northern blot analysis detected highest expression of a 4.1-kb transcript in heart, liver, placenta, prostate, testis, uterus, pancreas, small intestine, colon, and lymphoid organs, with lower expression in brain, skeletal muscle, kidney, and lung, and no expression in peripheral blood leukocytes. B7H3 expression was detected in most tumor cell lines tested.

Reference

"B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production."
Nat. Immunol. 2:269-274(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains."
J. Immunol. 172:2352-2359(2004) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss."
Genomics 82:365-377(2003) [PubMed] [Europe PMC] [Abstract]

"Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis."
Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645(2004) [PubMed] [Europe PMC] [Abstract]

"The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta."
Am. J. Pathol. 167:465-473(2005) [PubMed] [Europe PMC] [Abstract]

"Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells."
Am. J. Respir. Cell Mol. Biol. 33:280-289(2005) [PubMed] [Europe PMC] [Abstract]

"B7-H3: another molecule marker for Mo-DCs?"
Cell. Mol. Immunol. 2:307-311(2005) [PubMed] [Europe PMC] [Abstract]

"B7-H3 promotes acute and chronic allograft rejection."
Eur. J. Immunol. 35:428-438(2005) [PubMed] [Europe PMC] [Abstract]

"Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses."
Proc. Natl. Acad. Sci. U.S.A. 105:10495-10500(2008) [PubMed] [Europe PMC] [Abstract]

Erratum
Proc. Natl. Acad. Sci. U.S.A. 105:14744-14744(2008)

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]