Complement Factor P (CFP)
CF-P; PFC; Properdin
Properdin or factor P is a globulin protein found in the blood serum of more complex animals. In the complement system, an innate-immunity series of proenzymes dissolved in the circulation, it is also called "Factor P". It is known that it participates in some specific immune responses. It plays a part in tissue inflammation as well as the engulfing of pathogens by phagocytes. In addition it is known to help to neutralize some viruses.
As a component of the alternative pathway for complement activation (otherwise known as the "properdin pathway"), it complexes with another protein, C3b, to stabilize the alternative C3 convertase (C3bBb) that then cleaves more C3.Properdin was discovered in 1954 by Dr. Louis Pillemer of the Institute of Pathology .
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Hu01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Hu01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Hu01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Hu01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Hu01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Mu01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Mu01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Mu01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Mu01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Mu01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Ra01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Ra01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Ra01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Ra01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Ra01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Ca01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Ca01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Ca01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Ca01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Ca01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Po01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Po01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Po01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Po01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Po01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Bo01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Bo01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Bo01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Bo01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Bo01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Rb01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Rb01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Rb01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Rb01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Rb01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW029Mo01 | Recombinant Complement Factor P (CFP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW029Mo01 | Monoclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IP. |
| PAW029Mo01 | Polyclonal Antibody to Complement Factor P (CFP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW029Mo01 | CLIA Kit for Complement Factor P (CFP) | CLIA assay for Antigen Detection |
| ELW029Mo01 | ELISA Kit for Complement Factor P (CFP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement."
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"Characterization of the human properdin gene."
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"Detection of properdin mRNA in human peripheral blood monocytes and spleen."
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"Sequence-based analysis of properdin deficiency: identification of point mutations in two phenotypic forms of an X-linked immunodeficiency."
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"Properdin, the positive regulator of complement, is highly C-mannosylated."
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Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
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"Molecular characterization of properdin deficiency type III: dysfunction produced by a single point mutation in exon 9 of the structural gene causing a tyrosine to aspartic acid interchange."
J. Immunol. 157:3666-3671(1996) [PubMed] [Europe PMC] [Abstract]
"Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations."
J. Clin. Immunol. 18:272-282(1998) [PubMed] [Europe PMC] [Abstract]
"Molecular characterisation of 10 Dutch properdin type I deficient families: mutation analysis and X-inactivation studies."
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