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Kidney Injury Molecule 1 (Kim1)
Kidney Injury Molecule 1 (Kim1)
HAVCR1; TIM1; TIMD1; HAVCR; Hepatitis A Virus Cellular Receptor 1; T Cell Immunoglobulin And Mucin Domain-Containing Protein 1; T-cell immunoglobulin mucin receptor 1
kidney injury molecule-1 (KIM-1) is a type 1 transmembrane protein that is not detectable in normal kidney tissue but is expressed at high levels in rodent kidneys with dedifferentiated proximal tubule epithelial cells after ischemic or toxic injury.
Sequence analysis predicted that the 359-amino acid type I HAVCR1 glycoprotein, which is 79% identical to the monkey protein, contains a signal sequence; a 109-amino acid cys-rich N-terminal region with only 1 conserved N-glycosylation site; a 163-amino acid TSP-rich region with 3 N-glycosylation sites, 2 of which are conserved; and a 48-amino acid intracellular domain, 12 residues shorter than that of the monkey protein. Northern blot analysis revealed ubiquitous expression of a 4.4-kb HAVCR1 transcript, with highest levels in kidney and testis.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W027Ca01
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
PW027Ca01
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
W027Po01
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
PW027Po01
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
KEW027Po
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kidney Injury Molecule 1 (Kim1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kidney Injury Molecule 1 (Kim1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kidney Injury Molecule 1 (Kim1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kidney Injury Molecule 1 (Kim1) CLIA assay for Antigen Detection
Reference
"The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor." PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions." J. Virol. 81:3437-3446(2007) [PubMed ] [Europe PMC ] [Abstract ]
"Tubular kidney injury molecule-1 (KIM-1) in human renal disease." J. Pathol. 212:209-217(2007) [PubMed ] [Europe PMC ] [Abstract ]
"A quantitative atlas of mitotic phosphorylation." Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed ] [Europe PMC ] [Abstract ]
"Hepatitis A virus link to atopic disease." Nature 425:576-576(2003) [PubMed ] [Europe PMC ] [Abstract ]
