Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1)

CD274; PDL1; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1-LG1; Programed Death Ligand 1

SPN	W024
HGNC	17635
MGI	1926446
PubMed	20143437
RGD	1566211
UniProt	Q9NZQ7
Wiki	PD-L1

CD274 (Cluster of Differentiation 274) also known as PD-L1 (Programed Death Ligand-1) or B7-H1 is a protein,PD-L1 binds to its receptor, PD-1, found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition. The affinity between PD-L1 and PD-1, as defined by the dissociation constant K_d, is 770nM. Interestingly, PD-L1 also has an appreciable affinity for the costimulatory molecule CD80 (B7-1), but not CD86 (B7-2).

CD80's affinity for PD-L1, 1.4µM, is intermediate between its affinities for CD28 and CTLA-4 (4.0µM and 400nM, respectively). The related molecule PD-L2 has no such affinity for CD80 or CD86, but shares PD-1 as a receptor (with a stronger K_d of 140nM).

Reference

"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion."
Nat. Med. 5:1365-1369(1999) [PubMed] [Europe PMC] [Abstract]

"Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation."
J. Exp. Med. 192:1027-1034(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain."
Acta Pharmacol. Sin. 26:462-468(2005) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors."
Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016(2008) [PubMed] [Europe PMC] [Abstract]