Bone Morphogenetic Protein 7 (BMP7)
OP1; Osteogenic Protein-1; Eptotermin alfa
The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder.
BMP7 has been discovered to be crucial in the determination of ventral-dorsal organization in zebrafish. BMP7 causes the expression of ventral phenotypes while its complete inhibition creates a dorsal phenotype. Moreover, BMP7 is eventually partially "turned off" in embryonic development in order to create the dorsal parts of the organism.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Hu01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Hu01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Hu01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Hu01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Hu01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Mu01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Mu01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Mu01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Mu01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Mu01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Ra01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Ra01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Ra01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Ra01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Ra01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Ca01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Ca01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Ca01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Ca01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Ca01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Po01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Po01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Po01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Po01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Po01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Bo01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Bo01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Bo01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Bo01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Bo01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Rb01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Rb01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Rb01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Rb01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Rb01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW013Mo01 | Recombinant Bone Morphogenetic Protein 7 (BMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW013Mo01 | Monoclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IP. |
| PAW013Mo01 | Polyclonal Antibody to Bone Morphogenetic Protein 7 (BMP7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW013Mo01 | CLIA Kit for Bone Morphogenetic Protein 7 (BMP7) | CLIA assay for Antigen Detection |
| ELW013Mo01 | ELISA Kit for Bone Morphogenetic Protein 7 (BMP7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"OP-1 cDNA encodes an osteogenic protein in the TGF-beta family."
EMBO J. 9:2085-2093(1990) [PubMed] [Europe PMC] [Abstract]
"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."
Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Expression and characterization of a human BMP-7 variant with improved biochemical properties."
Protein Expr. Purif. 57:312-319(2008) [PubMed] [Europe PMC] [Abstract]
"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."
Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract]
"Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies."
Hum. Mutat. 31:781-787(2010) [PubMed] [Europe PMC] [Abstract]
"Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily."
Proc. Natl. Acad. Sci. U.S.A. 93:878-883(1996) [PubMed] [Europe PMC] [Abstract]