Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A)

CD266; TNFRSF12-A; FN14; TWEAKR; Tumour Necrosis Factor Related Weak Inducer Of Apoptosis; Fibroblast growth factor-inducible immediate-early response protein 14

SPN	V998
HGNC	18152
MGI	1351484
PubMed	20452679
RGD	631329
UniProt	Q9NP84
Wiki	TNFRSF12A

FN14 protein, which shares 82% amino acid identity with the mouse sequence, contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. Northern blot analysis detected increased FN14 expression in response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro. A 1.2-kb FN14 transcript was expressed at high levels in heart, placenta, and kidney, at intermediate levels in lung, skeletal muscle, and pancreas, and at low levels in brain and liver. In addition, elevated FN14 expression was found in human liver cancer cell lines and hepatocellular carcinoma specimens. Expression of mouse Fn14 was upregulated in hepatocellular carcinoma nodules that develop in 2 different transgenic mouse models of hepatocarcinogenesis.

Reference

"The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas."
Am. J. Pathol. 156:1253-1261(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis."
Immunity 15:837-846(2001) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the STN_TNFRSF12A_TNFR domain of tumor necrosis factor receptor superfamily member 12A precursor."
Submitted (APR-2008) to the PDB data bank

"Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily."
Protein Sci. 18:650-656(2009) [PubMed] [Europe PMC] [Abstract]