Corticotropin Releasing Hormone (CRH)
CRF; Corticotropin Releasing Factor; Corticoliberin
releasing factor was initially isolated from ovine hypothalamus by Vale et al., in 1981, and identified as a novel neuropeptide comprising 41 amino acid residues with molecular weight 4758. Later human CRF and rat CRF were also isolated and identified. The mouse CRF peptide is identical at amino acid level to the rat and human CRF peptides. CRF in anterior pituitary promotes the synthesis and secretion of ACTH, a main factor of hypothalamus-pituitary-adrenal (HPA) axis. In the rat and human, CRF distributes mainly in hypothalamus, but it was also found in spinal cord, stomach, spleen, duodenum, adrenal and placenta. In addition, immunochemical evidence supported the wide distribution of the peptide throughout the central nervous system (CNS) such as olfactory bulb, retina and central auditory system in the rat.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Hu01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Hu01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Hu01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Hu01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Hu01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Mu01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Mu01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Mu01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Mu01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Mu01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Ra01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Ra01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Ra01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Ra01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Ra01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Ca01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Ca01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Ca01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Ca01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Ca01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Po01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Po01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Po01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Po01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Po01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Bo01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Bo01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Bo01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Bo01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Bo01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Rb01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Rb01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Rb01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Rb01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Rb01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV976Mo01 | Recombinant Corticotropin Releasing Hormone (CRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV976Mo01 | Monoclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IP. |
| PAV976Mo01 | Polyclonal Antibody to Corticotropin Releasing Hormone (CRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV976Mo01 | CLIA Kit for Corticotropin Releasing Hormone (CRH) | CLIA assay for Antigen Detection |
| ELV976Mo01 | ELISA Kit for Corticotropin Releasing Hormone (CRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene."
EMBO J. 2:775-779(1983) [PubMed] [Europe PMC] [Abstract]
"Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing."
Mol. Cell. Endocrinol. 61:175-180(1989) [PubMed] [Europe PMC] [Abstract]
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta."
J. Clin. Endocrinol. Metab. 67:768-773(1988) [PubMed] [Europe PMC] [Abstract]
"Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics."
Protein Eng. 6:149-156(1993) [PubMed] [Europe PMC] [Abstract]
"Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1."
J. Biol. Chem. 283:32900-32912(2008) [PubMed] [Europe PMC] [Abstract]