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Lipoprotein, a (Lpa)

Lp(a); AK38; APOA; LP; Sinking Pre-β-Lipoprotein

Lipoprotein(a) consists of an LDL-like particle and the specific apolipoprotein(a) , which is covalently bound to the apoB of the LDL like particle. Lp(a) plasma concentrations are highly heritable and mainly controlled by the apolipoprotein(a) gene located on chromosome 6q26-27. Apo(a) proteins vary in size due to a size polymorphism , which is caused by a variable number of so called kringle IV repeats in the LPA gene. This size variation at the gene level is expressed on the protein level as well, resulting in apo(a) proteins with 10 to > 50 kringle IV repeats . These variable apo(a) sizes are known as "apo(a) isoforms". There is a general inverse correlation between the size of the apo(a)isoform and the Lp(a) plasma concentration which is caused by a variable rate of degradation before the apo(a) protein has matured for Lp(a) assembly.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V969Hu01 Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies MV969Hu22 Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
PV969Hu01 Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits KEV969Hu ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Lipoprotein, a (Lpa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Lipoprotein, a (Lpa) Bioactivity
Antibodies NONE Monoclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Lipoprotein, a (Lpa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Lipoprotein, a (Lpa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Lipoprotein, a (Lpa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Lipoprotein, a (Lpa) CLIA assay for Antigen Detection

Reference

"cDNA sequence of human apolipoprotein(a) is homologous to plasminogen."
Nature 330:132-137(1987) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"Amplification of human APO(a) kringle 4-37 from blood lymphocyte DNA."
Biochim. Biophys. Acta 1225:107-109(1993) [PubMed] [Europe PMC] [Abstract]

"Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it."
EMBO J. 8:4035-4040(1989) [PubMed] [Europe PMC] [Abstract]

"The mysteries of lipoprotein(a)."
Science 246:904-910(1989) [PubMed] [Europe PMC] [Abstract]

"Structural elucidation of the N- and O-glycans of human apolipoprotein(a): role of o-glycans in conferring protease resistance."
J. Biol. Chem. 276:22200-22208(2001) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of apolipoprotein(a) kringle IV37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: existence of novel and expected binding modes."
J. Mol. Biol. 256:751-761(1996) [PubMed] [Europe PMC] [Abstract]

"A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a)."
Biochim. Biophys. Acta 1227:41-45(1994) [PubMed] [Europe PMC] [Abstract]