Clara Cell Protein 16 (CC16)

SCGB1A1; CC10; CCSP; UGB; Uteroglobin; Urinary Protein 1; Clara Cell Secretory Protein; Secretoglobin Family 1A Member 1; Clara-Cell Specific 10-kD Protein

SPN	V954
HGNC	12523
MGI	98919
PubMed	23888888
RGD	3934
UniProt	P11684
Wiki	CC16

Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.

Reference

"Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein."
Biochim. Biophys. Acta 950:329-337(1988) [PubMed] [Europe PMC] [Abstract]

"Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease."
Am. J. Physiol. 268:L565-L575(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines."
Hum. Mol. Genet. 1:371-378(1992) [PubMed] [Europe PMC] [Abstract]

"Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein."
J. Chromatogr. A 577:25-35(1992) [PubMed] [Europe PMC] [Abstract]

"Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions."
Clin. Chim. Acta 207:239-249(1992) [PubMed] [Europe PMC] [Abstract]

"Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting."
Proteomics 2:112-120(2002) [PubMed] [Europe PMC] [Abstract]

"Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution."
Nat. Struct. Biol. 1:538-545(1994) [PubMed] [Europe PMC] [Abstract]