Epithelial Neutrophil Activating Peptide 78 (ENA78)
CXCL5; SCYB5; Chemokine C-X-C-Motif Ligand 5; Small Inducible Cytokine Subfamily B(Cys-X-Cys),Member 5; Neutrophil-activating peptide ENA-78
ENA-78 is a CXC chemokine that was originally isolated from media conditioned by the growth of a mouse lung type-II alveolar epithelial cell line (A549) stimulated by IL-1 or TNF. The full-length cDNA encodes a 114 amino acid (aa) residue precursor protein with a 36 aa residue signal peptide that is cleaved to generate the 78 aa residue secreted protein. ENA-78 shares significant amino acid sequence identity with NAP-2 (53%), GRO,, and (52%, 48% and 51%, respectively), and IL-8 (22%). The gene for ENA-78 has been mapped to chromosome 4q13-q21. Like other CXC chemokines, ENA-78 is a neutrophil attractant and activator in vitro. Based on cross-desensitization experiments, it has been suggested that ENA-78 activity can be mediated through the IL-8 receptor system.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Hu01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Hu01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Hu01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Hu01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Hu01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Mu01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Mu01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Mu01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Mu01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Mu01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Ra01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Ra01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Ra01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Ra01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Ra01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Ca01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Ca01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Ca01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Ca01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Ca01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Po01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Po01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Po01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Po01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Po01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Bo01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Bo01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Bo01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Bo01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Bo01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Rb01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Rb01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Rb01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Rb01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Rb01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV951Mo01 | Recombinant Epithelial Neutrophil Activating Peptide 78 (ENA78) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV951Mo01 | Monoclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IP. |
| PAV951Mo01 | Polyclonal Antibody to Epithelial Neutrophil Activating Peptide 78 (ENA78) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV951Mo01 | CLIA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | CLIA assay for Antigen Detection |
| ELV951Mo01 | ELISA Kit for Epithelial Neutrophil Activating Peptide 78 (ENA78) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets."
Gene 151:333-334(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene."
J. Biol. Chem. 269:25277-25282(1994) [PubMed] [Europe PMC] [Abstract]
"Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)."
Biochem. Biophys. Res. Commun. 205:612-617(1994) [PubMed] [Europe PMC] [Abstract]
"Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."
Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8."
J. Exp. Med. 174:1355-1362(1991) [PubMed] [Europe PMC] [Abstract]
"Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
"Regulation of the immune response by the interaction of chemokines and proteases."
Adv. Immunol. 81:1-44(2003) [PubMed] [Europe PMC] [Abstract]