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Pyruvate Dehydrogenase Phosphatase (PDP)

PDP1; PDH; PPM2C; Protein Phosphatase 2C Magnesium-Dependent Catalytic Subunit; Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1

Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic PPM2C is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V924Hu01 Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies MV924Hu22 Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
PV924Hu01 Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits KEV924Hu ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V924Mu01 Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
PV924Mu01 Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Pyruvate Dehydrogenase Phosphatase (PDP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Pyruvate Dehydrogenase Phosphatase (PDP) Bioactivity
Antibodies NONE Monoclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Pyruvate Dehydrogenase Phosphatase (PDP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Pyruvate Dehydrogenase Phosphatase (PDP) CLIA assay for Antigen Detection

Reference

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Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation."
J. Clin. Endocrinol. Metab. 90:4101-4107(2005) [PubMed] [Europe PMC] [Abstract]