Renin (REN)
angiotensinogenase
Renin is a member of the aspartyl proteinase family produced largely in part by the juxtaglomerular cells in the kidney.Renin differs from the other members of this class by having a pH optimum near neutral pH region with native substrates instead of 2.0 to 3.4 This more neutral pH optimum allows it to be functional in the plasma.
Renin also has very high selectivity for substrate due to quite long peptide recognition on either side of the peptide bond undergoing cleavage. An octapeptide substrate was the minimum length to be cleaved by renin. Renin plays a crucial role in the regulation of blood pressure and salt balance through the cleavage of angiotensinogen, which is the only known physiological substrate of renin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Hu01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Hu01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Hu01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Hu01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Hu01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Mu01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Mu01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Mu01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Mu01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Mu01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Ra01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Ra01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Ra01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Ra01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Ra01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Ca01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Ca01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Ca01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Ca01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Ca01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Po01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Po01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Po01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Po01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Po01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Bo01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Bo01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Bo01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Bo01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Bo01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Rb01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Rb01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Rb01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Rb01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Rb01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV922Mo01 | Recombinant Renin (REN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV922Mo01 | Monoclonal Antibody to Renin (REN) | WB; IHC; ICC; IP. |
| PAV922Mo01 | Polyclonal Antibody to Renin (REN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV922Mo01 | CLIA Kit for Renin (REN) | CLIA assay for Antigen Detection |
| ELV922Mo01 | ELISA Kit for Renin (REN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and sequence analysis of cDNA for human renin precursor."
Proc. Natl. Acad. Sci. U.S.A. 80:7405-7409(1983) [PubMed] [Europe PMC] [Abstract]
"New possibilities for intracellular renin and inactive renin now that the structure of the human renin gene has been elucidated."
Clin. Sci. 71:345-355(1986) [PubMed] [Europe PMC] [Abstract]
"Primary structure of the human renin gene."
DNA 3:457-468(1984) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and nucleotide sequence of a human renin cDNA fragment."
Nucleic Acids Res. 11:7181-7190(1983) [PubMed] [Europe PMC] [Abstract]
"Human renin gene of renin-secreting tumor."
Gene 49:139-145(1986) [PubMed] [Europe PMC] [Abstract]
"Identification of negative and positive regulatory elements in the human renin gene."
J. Biol. Chem. 264:7357-7362(1989) [PubMed] [Europe PMC] [Abstract]
"Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions."
Gene 41:85-92(1986) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of recombinant human prorenin in Chinese hamster ovary cells."
J. Biochem. 109:30-35(1991) [PubMed] [Europe PMC] [Abstract]
"Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin."
J. Clin. Invest. 109:1417-1427(2002) [PubMed] [Europe PMC] [Abstract]
"Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5-A resolution."
Science 243:1346-1351(1989) [PubMed] [Europe PMC] [Abstract]
"X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins."
Nature 357:466-472(1992) [PubMed] [Europe PMC] [Abstract]
"A redox switch in angiotensinogen modulates angiotensin release."
Nature 468:108-111(2010) [PubMed] [Europe PMC] [Abstract]
"Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."
Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]
"Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure."
Am. J. Hum. Genet. 85:204-213(2009) [PubMed] [Europe PMC] [Abstract]