Surfactant Associated Protein A (SPA)
PRL; SFTPA; PSAP; PSPA; SFTP; SFTPA1; COLEC4; PSP-A; SFTP1; SFTPA1B; SP-A1; Collectin-4; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein
SP-A (PRL) is a peptide hormone primarily associated with lactation. In breastfeeding, the infant suckling the teat stimulates the production of SP-A, which fills the breast with milk (lactogenesis) in preparation for the next feed. Oxytocin, a similar hormone, is also released, which triggers milk let-down. SP-A (PRL) is a polypeptide hormone secreted by anterior pituitary of both male and female. Release of SP-A is controlled by a complex neuroendocrine reflex initiated by a tactile stimulus and regulated by hypothalamic releasing and inhibition. Genetic variations in SFTPA1 are associated with respiratory distress syndrome in premature infants (RDS) ; also known as RDS in prematurity. RDS in the newborn is the main cause of mortality and morbidity in premature infants.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Hu01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Hu01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Hu01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Hu01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Hu01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Mu01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Mu01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Mu01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Mu01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Mu01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Ra01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Ra01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Ra01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Ra01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Ra01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Ca01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Ca01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Ca01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Ca01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Ca01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Po01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Po01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Po01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Po01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Po01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Bo01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Bo01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Bo01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Bo01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Bo01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Rb01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Rb01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Rb01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Rb01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Rb01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV921Mo01 | Recombinant Surfactant Associated Protein A (SPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV921Mo01 | Monoclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IP. |
| PAV921Mo01 | Polyclonal Antibody to Surfactant Associated Protein A (SPA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV921Mo01 | CLIA Kit for Surfactant Associated Protein A (SPA) | CLIA assay for Antigen Detection |
| ELV921Mo01 | ELISA Kit for Surfactant Associated Protein A (SPA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation and characterization of the human pulmonary surfactant apoprotein gene."
Nature 317:361-363(1985) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein."
J. Biol. Chem. 261:9029-9033(1986) [PubMed] [Europe PMC] [Abstract]
"Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene."
Am. J. Physiol. 299:L523-L534(2010) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Studies of the structure of lung surfactant protein SP-A."
Am. J. Physiol. 257:L421-L429(1989) [PubMed] [Europe PMC] [Abstract]
"Genetics of the hydrophilic surfactant proteins A and D."
Biochim. Biophys. Acta 1408:312-322(1998) [PubMed] [Europe PMC] [Abstract]
"Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population."
Am. J. Hum. Genet. 66:1569-1579(2000) [PubMed] [Europe PMC] [Abstract]
"Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis."
Hum. Genet. 113:542-550(2003) [PubMed] [Europe PMC] [Abstract]
"Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]