Arachidonate-15-Lipoxygenase (ALOX15)

LOX15; 15-LOX2; 15-LOX1; 15-LOX; 12-LOX; ALOX15; 15-LO; 15-LPG; LOG15; Lipoxygenase 15; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate omega-6 lipoxygenase

SPN	V920
HGNC	433
MGI	87997
PubMed	14716014
RGD	70493
UniProt	P16050
Wiki	ALOX15

Yoshimoto et al. (1990) found that the amino acid sequence of human reticulocyte 15-lipoxygenase (Sigal et al., 1988) showed 86% identity with that of porcine leukocyte 12-lipoxygenase. Sigal et al. (1988) found 61% sequence similarity between 15-lipoxygenase and 5-lipoxygenase. This suggests that in the human 12-lipoxygenase is more closely related evolutionarily to 15-lipoxygenase than to 5-lipoxygenase, even though the comparisons are made between human and porcine enzymes. By PCR analysis of a human-hamster somatic hybrid DNA panel, Funk et al. (1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10.

Reference

"Molecular cloning and primary structure of human 15-lipoxygenase."
Biochem. Biophys. Res. Commun. 157:457-464(1988) [PubMed] [Europe PMC] [Abstract]

"Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene."
Biochim. Biophys. Acta 1352:267-281(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes."
Mol. Biol. Rep. 25:173-182(1998) [PubMed] [Europe PMC] [Abstract]

"Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases."
J. Biol. Chem. 263:5328-5332(1988) [PubMed] [Europe PMC] [Abstract]

"Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes."
Eur. J. Biochem. 202:1231-1238(1991) [PubMed] [Europe PMC] [Abstract]

"A primary determinant for lipoxygenase positional specificity."
Nature 354:149-152(1991) [PubMed] [Europe PMC] [Abstract]

"Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme."
Blood 91:64-74(1998) [PubMed] [Europe PMC] [Abstract]

"Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells."
Prostaglandins Leukot. Essent. Fatty Acids 64:217-225(2001) [PubMed] [Europe PMC] [Abstract]

"Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity."
Biochim. Biophys. Acta 1761:1498-1505(2006) [PubMed] [Europe PMC] [Abstract]

"Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes."
FEBS Lett. 582:3249-3253(2008) [PubMed] [Europe PMC] [Abstract]

"15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism."
J. Lipid Res. 50:2371-2376(2009) [PubMed] [Europe PMC] [Abstract]

"15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells."
Proc. Natl. Acad. Sci. U.S.A. 108:14246-14251(2011) [PubMed] [Europe PMC] [Abstract]

"A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease."
Atherosclerosis 198:136-144(2008) [PubMed] [Europe PMC] [Abstract]