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Lymphocyte Function Associated Antigen 3 (LFA3)
Lymphocyte Function Associated Antigen 3 (LFA3)
CD58; Ag3; Surface glycoprotein LFA-3
CD58, also known as lymphocyte function-associated antigen (LFA-3), is a 210 amino acid protein that belongs to the CD2 family of the immunoglobulin superfamily.1 CD58 is widely expressed on hematopoietic and non-hematopoietic human tissue and has been found on leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts of human origin.2 No mouse or rat homolog of CD58 has as of yet been identified. CD58 has only one known ligand, CD2. CD2 is expressed on T cells, NK cells and Dendritic cells. CD2 ligation by CD58 has been shown to mediate T cell adhesion, T cell activation, T cell cytokine production and T cell and NK cells cytotoxic activity. In dendritic cells, CD2 engagement increases MHC Class II, CD40, CD80, CD86, CD58 and CCR7 and induces IL-1beta; IL-12 cytokine secretion.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Lymphocyte Function Associated Antigen 3 (LFA3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Lymphocyte Function Associated Antigen 3 (LFA3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Lymphocyte Function Associated Antigen 3 (LFA3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Lymphocyte Function Associated Antigen 3 (LFA3) CLIA assay for Antigen Detection
Reference
"Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein." J. Exp. Med. 166:923-932(1987) [PubMed ] [Europe PMC ] [Abstract ]
"An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2." Nature 329:840-842(1987) [PubMed ] [Europe PMC ] [Abstract ]
"Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene." J. Immunol. 160:2862-2871(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed ] [Europe PMC ] [Abstract ]
"An unappreciated role for RNA surveillance." Genome Biol. 5:R8.1-R8.16(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment." J. Proteome Res. 5:935-943(2006) [PubMed ] [Europe PMC ] [Abstract ]
"Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors." Cell 97:791-803(1999) [PubMed ] [Europe PMC ] [Abstract ]
"Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution." Proc. Natl. Acad. Sci. U.S.A. 96:4289-4294(1999) [PubMed ] [Europe PMC ] [Abstract ]