Prostaglandin E Synthase 2 (PTGES2)

C9orf15; PGES2; mPGES-2; Chromosome 9 Open Reading Frame 15; Microsomal prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form

SPN	V906
HGNC	17822
MGI	1917592
PubMed	17979097
RGD	1310836
UniProt	Q9H7Z7
Wiki	PTGES2

• PTGES2 catalyzes the conversion of prostaglandin H2 to prostaglandin E2 (Tanikawa et al). It also activates transcription from a gamma-interferon (IFNG)-activated transcriptional element, or GATE.

• Tanikawa et al. (2002) identified monkey and human cDNAs encoding proteins homologous to Ptges2 purified from the microsomal fraction of bovine heart. The monkey and human cDNAs encode 377-amino acid proteins that share 97% identity. Both proteins have 87 additional N-terminal amino acids compared with the purified bovine Ptges2, and they both have a consensus region shared with glutaredoxin and thioredoxin.Hu et al. (2002) cloned mouse Ptges2, which they designated Gbf1. The deduced protein contains 384 amino acids and has a calculated molecular mass of about 38 kD.

Reference

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