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Dopamine Receptor D4 (DRD4)

DR-D4; D4R; D4DR; D(2C) dopamine receptor

The  is the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

The 'DRD4 long' variant, or more specifically the 7 repeat (7R), has been loosely linked to a susceptibility for developing ADHD and other psychological traits and disorders, like autism.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V886Ra01 Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies MV886Ra21 Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
PV886Ra01 Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dopamine Receptor D4 (DRD4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dopamine Receptor D4 (DRD4) Bioactivity
Antibodies NONE Monoclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dopamine Receptor D4 (DRD4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dopamine Receptor D4 (DRD4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dopamine Receptor D4 (DRD4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dopamine Receptor D4 (DRD4) CLIA assay for Antigen Detection

Reference

"Multiple dopamine D4 receptor variants in the human population."
Nature 358:149-152(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine."
Nature 350:610-614(1991) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"A hypervariable segment in the human dopamine receptor D4 (DRD4) gene."
Hum. Mol. Genet. 2:767-773(1993) [PubMed] [Europe PMC] [Abstract]

"Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes."
Mol. Pharmacol. 46:364-373(1994) [PubMed] [Europe PMC] [Abstract]

"Modulation of postendocytic sorting of G protein-coupled receptors."
Science 297:615-620(2002) [PubMed] [Europe PMC] [Abstract]

"BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase."
J. Biol. Chem. 283:11083-11096(2008) [PubMed] [Europe PMC] [Abstract]

"The dopamine D(4) receptor, the ultimate disordered protein."
J. Recept. Signal Transduct. 30:331-336(2010) [PubMed] [Europe PMC] [Abstract]

"KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation."
Cell. Signal. 22:900-913(2010) [PubMed] [Europe PMC] [Abstract]

"Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions."
Biochem. Biophys. Res. Commun. 404:928-934(2011) [PubMed] [Europe PMC] [Abstract]

"Molecular modelling of D2-like dopamine receptors."
Biochem. J. 287:277-282(1992) [PubMed] [Europe PMC] [Abstract]

"Dopamine D4 receptor variant, D4-glycine-194, in Africans, but not in Caucasians: no association with schizophrenia."
Am. J. Med. Genet. 54:384-390(1994) [PubMed] [Europe PMC] [Abstract]