Tumor Protein p53 (TP53)
p53; LFS1; TRP53; Li-Fraumeni Syndrome; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
The p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V883Hu01 | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | MV883Hu22 | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| PV883Hu01 | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| LV883Hu71 | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV883Hu | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCV883Hu | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V883Mu01 | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| PV883Mu01 | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV883Mu | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | V883Ra01 | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | MV883Ra21 | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| PV883Ra01 | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEV883Ra | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tumor Protein p53 (TP53) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tumor Protein p53 (TP53) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tumor Protein p53 (TP53) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tumor Protein p53 (TP53) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tumor Protein p53 (TP53) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tumor Protein p53 (TP53) | CLIA assay for Antigen Detection |
Reference
"Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells."
EMBO J. 4:1251-1255(1985) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human p53 gene."
Mol. Cell. Biol. 6:1379-1385(1986) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53."
Mol. Cell. Biol. 5:1601-1610(1985) [PubMed] [Europe PMC] [Abstract]
"Molecular basis for heterogeneity of the human p53 protein."
Mol. Cell. Biol. 6:4650-4656(1986) [PubMed] [Europe PMC] [Abstract]
"A variation in the structure of the protein-coding region of the human p53 gene."
Gene 70:245-252(1988) [PubMed] [Europe PMC] [Abstract]
"p53 is frequently mutated in Burkitt's lymphoma cell lines."
EMBO J. 10:2879-2887(1991) [PubMed] [Europe PMC] [Abstract]
"Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs."
Radiat. Res. 134:349-354(1993) [PubMed] [Europe PMC] [Abstract]
"Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity."
J. Biol. Chem. 276:3361-3370(2001) [PubMed] [Europe PMC] [Abstract]
"p53 isoforms can regulate p53 transcriptional activity."
Genes Dev. 19:2122-2137(2005) [PubMed] [Europe PMC] [Abstract]
"Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8."
Radiat. Res. 154:473-476(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin."
Proc. Natl. Acad. Sci. U.S.A. 100:15836-15841(2003) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene."
EMBO J. 3:3257-3262(1984) [PubMed] [Europe PMC] [Abstract]
"The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif."
Oncogene 5:423-426(1990) [PubMed] [Europe PMC] [Abstract]
"Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2."
Proc. Natl. Acad. Sci. U.S.A. 87:4766-4770(1990) [PubMed] [Europe PMC] [Abstract]
"The tumor suppressor p53 is bound to RNA by a stable covalent linkage."
Mol. Cell. Biol. 11:1598-1606(1991) [PubMed] [Europe PMC] [Abstract]
"Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen."
Mol. Cell. Biol. 11:1996-2003(1991) [PubMed] [Europe PMC] [Abstract]
"The human tumour suppressor gene p53 is alternatively spliced in normal cells."
Oncogene 12:813-818(1996) [PubMed] [Europe PMC] [Abstract]
"Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus."
Oncogene 12:921-930(1996) [PubMed] [Europe PMC] [Abstract]
"p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner."
Mol. Cell. Biol. 17:7220-7229(1997) [PubMed] [Europe PMC] [Abstract]
"Regulation of CAK kinase activity by p53."
Oncogene 17:2733-2741(1998) [PubMed] [Europe PMC] [Abstract]
"Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1."
EMBO J. 18:6462-6471(1999)
"Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15."
FEBS Lett. 463:312-316(1999) [PubMed] [Europe PMC] [Abstract]
"A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain."
J. Biol. Chem. 274:32699-32703(1999) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage."
Proc. Natl. Acad. Sci. U.S.A. 96:13777-13782(1999) [PubMed] [Europe PMC] [Abstract]
"Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53."
J. Biol. Chem. 275:8945-8951(2000) [PubMed] [Europe PMC] [Abstract]
"Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry."
J. Mol. Biol. 295:853-864(2000) [PubMed] [Europe PMC] [Abstract]
"The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A."
J. Mol. Biol. 300:503-518(2000) [PubMed] [Europe PMC] [Abstract]
"The function of PML in p53-dependent apoptosis."
Nat. Cell Biol. 2:730-736(2000) [PubMed] [Europe PMC] [Abstract]
"p53 is involved in the p120E4F-mediated growth arrest."
Oncogene 19:188-199(2000) [PubMed] [Europe PMC] [Abstract]
"The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein."
Oncogene 19:3656-3664(2000) [PubMed] [Europe PMC] [Abstract]
"Zinc binding and redox control of p53 structure and function."
Antioxid. Redox Signal. 3:611-623(2001) [PubMed] [Europe PMC] [Abstract]
"Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line."
Biochem. Biophys. Res. Commun. 287:562-567(2001) [PubMed] [Europe PMC] [Abstract]
"hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase."
Cell 107:149-159(2001) [PubMed] [Europe PMC] [Abstract]
"p53 amino acids 339-346 represent the minimal p53 repression domain."
J. Biol. Chem. 276:1510-1515(2001) [PubMed] [Europe PMC] [Abstract]
"Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3."
J. Biol. Chem. 276:36194-36199(2001) [PubMed] [Europe PMC] [Abstract]
"Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway."
J. Biol. Chem. 276:43305-43312(2001) [PubMed] [Europe PMC] [Abstract]
"SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting."
J. Biol. Chem. 276:12654-12659(2001) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes."
J. Biol. Chem. 276:44003-44011(2001) [PubMed] [Europe PMC] [Abstract]
"A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1."
Mol. Cell 7:283-292(2001) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde."
Cell 111:1041-1054(2002) [PubMed] [Europe PMC] [Abstract]
"Differential effect of ik3-1/cables on p53- and p73-induced cell death."
J. Biol. Chem. 277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo."
J. Biol. Chem. 277:32020-32028(2002) [PubMed] [Europe PMC] [Abstract]
"Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2."
Nat. Cell Biol. 4:1-10(2002) [PubMed] [Europe PMC] [Abstract]
"Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis."
Nat. Cell Biol. 4:11-19(2002) [PubMed] [Europe PMC] [Abstract]
"p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity."
Cancer Res. 63:2373-2378(2003) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305."
J. Biol. Chem. 278:25568-25576(2003) [PubMed] [Europe PMC] [Abstract]
"The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation."
J. Biol. Chem. 278:33134-33141(2003) [PubMed] [Europe PMC] [Abstract]
"TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity."
J. Biol. Chem. 278:37722-37729(2003) [PubMed] [Europe PMC] [Abstract]
"Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination."
Mol. Cell. Biol. 23:6396-6405(2003) [PubMed] [Europe PMC] [Abstract]
"Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)."
Proc. Natl. Acad. Sci. U.S.A. 100:5431-5436(2003) [PubMed] [Europe PMC] [Abstract]
"Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control."
Biochem. J. 380:605-610(2004) [PubMed] [Europe PMC] [Abstract]
"Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53."
Cell 117:735-748(2004) [PubMed] [Europe PMC] [Abstract]
"The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle."
J. Mol. Biol. 339:313-325(2004) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression."
Mol. Cell 13:867-878(2004) [PubMed] [Europe PMC] [Abstract]
"A dynamic role of HAUSP in the p53-Mdm2 pathway."
Mol. Cell 13:879-886(2004) [PubMed] [Europe PMC] [Abstract]
"Regulation of human p53 activity and cell localization by alternative splicing."
Mol. Cell. Biol. 24:7987-7997(2004) [PubMed] [Europe PMC] [Abstract]
"Regulation of p53 activity through lysine methylation."
Nature 432:353-360(2004) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53."
Nat. Genet. 36:55-62(2004) [PubMed] [Europe PMC] [Abstract]
"NIR is a novel INHAT repressor that modulates the transcriptional activity of p53."
Genes Dev. 19:2912-2924(2005) [PubMed] [Europe PMC] [Abstract]
"Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif."
J. Biol. Chem. 280:16019-16029(2005) [PubMed] [Europe PMC] [Abstract]
"Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53."
J. Biol. Chem. 280:25008-25021(2005) [PubMed] [Europe PMC] [Abstract]
"WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53."
J. Biol. Chem. 280:43100-43108(2005) [PubMed] [Europe PMC] [Abstract]
"AMP-activated protein kinase induces a p53-dependent metabolic checkpoint."
Mol. Cell 18:283-293(2005) [PubMed] [Europe PMC] [Abstract]
"LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation."
Cancer Res. 66:10701-10708(2006) [PubMed] [Europe PMC] [Abstract]
"The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines."
FEBS J. 273:2487-2504(2006) [PubMed] [Europe PMC] [Abstract]
"Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon."
FEBS Lett. 580:305-310(2006) [PubMed] [Europe PMC] [Abstract]
"Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage."
J. Biol. Chem. 281:5734-5740(2006) [PubMed] [Europe PMC] [Abstract]
"Repression of p53 activity by Smyd2-mediated methylation."
Nature 444:629-632(2006) [PubMed] [Europe PMC] [Abstract]
"Critical role for Daxx in regulating Mdm2."
Nat. Cell Biol. 8:855-862(2006) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the methylation site specificity of SET7/9."
Nat. Struct. Mol. Biol. 13:140-146(2006) [PubMed] [Europe PMC] [Abstract]
"PRAK is essential for ras-induced senescence and tumor suppression."
Cell 128:295-308(2007) [PubMed] [Europe PMC] [Abstract]
"Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation."
Cell 130:624-637(2007) [PubMed] [Europe PMC] [Abstract]
"Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'."
EMBO J. 26:113-122(2007) [PubMed] [Europe PMC] [Abstract]
"A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55."
EMBO J. 26:402-411(2007) [PubMed] [Europe PMC] [Abstract]
"SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53."
FEBS Lett. 581:4943-4948(2007) [PubMed] [Europe PMC] [Abstract]
"Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9."
FEBS Lett. 581:5649-5657(2007) [PubMed] [Europe PMC] [Abstract]
"Nine-amino-acid transactivation domain: establishment and prediction utilities."
Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
"CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation."
J. Biol. Chem. 282:3273-3281(2007) [PubMed] [Europe PMC] [Abstract]
"The notch regulator MAML1 interacts with p53 and functions as a coactivator."
J. Biol. Chem. 282:11969-11981(2007) [PubMed] [Europe PMC] [Abstract]
"Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death."
J. Cell Sci. 120:2259-2271(2007) [PubMed] [Europe PMC] [Abstract]
"DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage."
Mol. Cell 25:725-738(2007) [PubMed] [Europe PMC] [Abstract]
"p53 is regulated by the lysine demethylase LSD1."
Nature 449:105-108(2007) [PubMed] [Europe PMC] [Abstract]
"Modulation of p53 function by SET8-mediated methylation at lysine 382."
Mol. Cell 27:636-646(2007) [PubMed] [Europe PMC] [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
"Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53."
Biochem. Biophys. Res. Commun. 368:690-695(2008) [PubMed] [Europe PMC] [Abstract]
"Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes."
Cell. Signal. 20:1671-1678(2008) [PubMed] [Europe PMC] [Abstract]
"Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation."
Mol. Cell 29:9-22(2008) [PubMed] [Europe PMC] [Abstract]
"Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A."
Mol. Cell. Biol. 28:448-456(2008) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis."
EMBO J. 28:2100-2113(2009) [PubMed] [Europe PMC] [Abstract]
"Plk1-mediated phosphorylation of Topors regulates p53 stability."
J. Biol. Chem. 284:18588-18592(2009) [PubMed] [Europe PMC] [Abstract]
"MTA1 coregulator regulates p53 stability and function."
J. Biol. Chem. 284:34545-34552(2009) [PubMed] [Europe PMC] [Abstract]
"Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein."
J. Virol. 83:12388-12398(2009) [PubMed] [Europe PMC] [Abstract]
"JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation."
Proc. Natl. Acad. Sci. U.S.A. 106:10195-10200(2009) [PubMed] [Europe PMC] [Abstract]
"Trim24 targets endogenous p53 for degradation."
Proc. Natl. Acad. Sci. U.S.A. 106:11612-11616(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"USP10 regulates p53 localization and stability by deubiquitinating p53."
Cell 140:384-396(2010) [PubMed] [Europe PMC] [Abstract]
"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response."
Cell 142:409-419(2010) [PubMed] [Europe PMC] [Abstract]
"Isoform specific phosphorylation of p53 by protein kinase CK1."
Cell. Mol. Life Sci. 67:1105-1118(2010) [PubMed] [Europe PMC] [Abstract]
"p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma."
FEBS Lett. 584:2231-2236(2010) [PubMed] [Europe PMC] [Abstract]
"Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival."
J. Biol. Chem. 285:1743-1753(2010) [PubMed] [Europe PMC] [Abstract]
"G9a and Glp methylate lysine 373 in the tumor suppressor p53."
J. Biol. Chem. 285:9636-9641(2010) [PubMed] [Europe PMC] [Abstract]
Erratum
J. Biol. Chem. 285:18122-18122(2010)
"G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis."
J. Biol. Chem. 285:12823-12830(2010) [PubMed] [Europe PMC] [Abstract]
"BRD7 is a candidate tumour suppressor gene required for p53 function."
Nat. Cell Biol. 12:380-389(2010) [PubMed] [Europe PMC] [Abstract]
"RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage."
Proc. Natl. Acad. Sci. U.S.A. 107:4579-4584(2010) [PubMed] [Europe PMC] [Abstract]
"Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence."
Proc. Natl. Acad. Sci. U.S.A. 107:14280-14285(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor."
Cell Cycle 10:3284-3299(2011) [PubMed] [Europe PMC] [Abstract]
"Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression."
J. Biol. Chem. 286:2236-2244(2011) [PubMed] [Europe PMC] [Abstract]
"A germline variant in the TP53 polyadenylation signal confers cancer susceptibility."
Nat. Genet. 43:1098-1103(2011) [PubMed] [Europe PMC] [Abstract]
"A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation."
Oncogene 30:2933-2942(2011) [PubMed] [Europe PMC] [Abstract]
"p53 opens the mitochondrial permeability transition pore to trigger necrosis."
Cell 149:1536-1548(2012) [PubMed] [Europe PMC] [Abstract]
"The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest."
Cell Cycle 11:407-417(2012) [PubMed] [Europe PMC] [Abstract]