Intelectin 1 (ITLN1)
HL1; INTL; ITLN; LFR; HIntL; Omentin; Intelectin 1,Galactofuranose Binding; Intestinal Lactoferrin Receptor;Endothelial lectin HL-1
Omentin is a protein expressed and secreted from visceral but not subcutaneous adipose tissue that increases insulin sensitivity in human adipocytes. To determine the impact of obesity-dependent insulin resistance on the regulation of two omentin isoforms, gene expression and plasma levels were measured in lean, overweight, and obese subjects.
Intelectin-1 is a 40 kDa Ca-dependent galactofuranose-binding lectin that is not a C-type lectin. Human ITLN-1 exists as a disulfide-linked glycosylated homotrimer. Mouse ITLN-1 is unglycosylated and a monomer. Mature human ITLN-1 is 82% aa identical to mouse ITLN-1. Human ITLN-1 shows one alternate start site at Met72, and a splice form that contains a 32 aa substitution for aa 264-313.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Hu01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Hu01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Hu01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Hu01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Hu01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Mu01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Mu01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Mu01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Mu01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Mu01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Ra01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Ra01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Ra01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Ra01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Ra01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Ca01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Ca01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Ca01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Ca01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Ca01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Po01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Po01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Po01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Po01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Po01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Bo01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Bo01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Bo01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Bo01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Bo01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Rb01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Rb01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Rb01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Rb01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Rb01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV878Mo01 | Recombinant Intelectin 1 (ITLN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV878Mo01 | Monoclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IP. |
| PAV878Mo01 | Polyclonal Antibody to Intelectin 1 (ITLN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV878Mo01 | CLIA Kit for Intelectin 1 (ITLN1) | CLIA assay for Antigen Detection |
| ELV878Mo01 | ELISA Kit for Intelectin 1 (ITLN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and functional expression of a human intestinal lactoferrin receptor."
Biochemistry 40:15771-15779(2001) [PubMed] [Europe PMC] [Abstract]
"Human homologs of the Xenopus oocyte cortical granule lectin XL35."
Glycobiology 11:65-73(2001) [PubMed] [Europe PMC] [Abstract]
"Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall."
J. Biol. Chem. 276:23456-23463(2001) [PubMed] [Europe PMC] [Abstract]
"The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins."
Comp. Biochem. Physiol. 137A:115-129(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action."
Am. J. Physiol. 290:E1253-E1261(2006) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer."
Glycobiology 17:1045-1051(2007) [PubMed] [Europe PMC] [Abstract]