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Chemokine C-X-C-Motif Receptor 4 (CXCR4)

CD184; Fusin; NPYR; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYRL; WHIM; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide-associated protein 3

CXCR4 is an alpha-chemokine receptor specific for stromal-derived-factor-1, a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4 T cells. Traditionally, HIV isolates that use CXCR4 are known as T-cell tropic isolates. Typically these viruses are found late in infection. It is unclear whether the emergence of CXCR4-using HIV is a consequence or a cause of immunodeficiency. CXCR4 is upregulated during the implantation window in natural and Hormone Replacement Therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Hu01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Hu01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Hu01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Hu01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Hu01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Mu01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Mu01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Mu01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Mu01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Mu01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Ra01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Ra01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Ra01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Ra01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Ra01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Ca01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Ca01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Ca01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Ca01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Ca01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Po01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Po01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Po01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Po01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Po01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Bo01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Bo01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Bo01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Bo01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Bo01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Rb01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Rb01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Rb01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Rb01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Rb01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV871Mo01 Recombinant Chemokine C-X-C-Motif Receptor 4 (CXCR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV871Mo01 Monoclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IP.
PAV871Mo01 Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 4 (CXCR4) WB; IHC; ICC; IF.
Assay Kits CLV871Mo01 CLIA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) CLIA assay for Antigen Detection
ELV871Mo01 ELISA Kit for Chemokine C-X-C-Motif Receptor 4 (CXCR4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Erratum
Nature 384:288-288(1996)

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"The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4."
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"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
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"Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling."
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"CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin."
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"F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse."
J. Cell Sci. 123:1160-1170(2010) [PubMed] [Europe PMC] [Abstract]

"Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4."
Mol. Biol. Cell 21:2529-2541(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway."
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"Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity."
Blood 119:4908-4918(2012) [PubMed] [Europe PMC] [Abstract]

"Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)."
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"Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists."
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