Immunoglobulin Lambda Like Polypeptide 1 (IglL1)

CD179b; IGL1; IGL5; IGLL; IGO; IGVPB; VPREB2; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1

SPN	V870
HGNC	5870
MGI	96529
PubMed	14976526
UniProt	P15814
Wiki	IGLL1

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This IGLL1 gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made.

Reference

"Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein."
Proc. Natl. Acad. Sci. U.S.A. 86:5552-5556(1989) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution."
J. Exp. Med. 173:305-311(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene."
Int. Immunol. 2:201-207(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of three new Ig lambda-like genes in man."
J. Exp. Med. 163:425-435(1986) [PubMed] [Europe PMC] [Abstract]

"Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia."
J. Exp. Med. 187:71-77(1998) [PubMed] [Europe PMC] [Abstract]

"Structural insight into pre-B cell receptor function."
Science 316:291-294(2007) [PubMed] [Europe PMC] [Abstract]