Chemerin (CHEM)

TIG2; RARRES2; Tazarotene-Induced Gene 2; Retinoic Acid Receptor Responder 2,Tazarotene Induced; RAR-responsive protein TIG2

SPN	V866
HGNC	9868
MGI	1918910
PubMed	20237162
RGD	1309874
UniProt	Q99969
Wiki	Chemerin

Chemerin is a novel protein identified as the natural ligand of ChemR23 (chemerinR), a previously orphan G protein-coupled receptor expressed in immature dendritic cells and macrophages. It is a member of the Cystatin superfamily. Chemerin is synthesized as a 163 aa secreted precursor, prochemerin, which contains a hydrophobic 20 aa N-terminal sequence, an intervening 137 aa Cystatin fold-containing domain, and a six aa C-terminal prosegment. It is activated by proteases of the coagulation, fibrinolytic, and inflammatory cascades and converted into a full agonist of chemerinR by proteolytic removal of the last six amino acids.Chemerin is a chemoattractant for cells bearing the Chem R23 receptor, including plasmacytoid dendritic cells and tissue macrophages.

Reference

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"Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades."
J. Biol. Chem. 280:34661-34666(2005) [PubMed] [Europe PMC] [Abstract]

"Chemerin--a new adipokine that modulates adipogenesis via its own receptor."
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"Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism."
J. Biol. Chem. 282:28175-28188(2007) [PubMed] [Europe PMC] [Abstract]

"Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes."
FEBS Lett. 582:573-578(2008) [PubMed] [Europe PMC] [Abstract]

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J. Clin. Endocrinol. Metab. 95:2476-2485(2010) [PubMed] [Europe PMC] [Abstract]

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Trends Endocrinol. Metab. 21:660-667(2010) [PubMed] [Europe PMC] [Abstract]

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Cytokine Growth Factor Rev. 22:331-338(2011) [PubMed] [Europe PMC] [Abstract]

"A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells."
Biochem. Biophys. Res. Commun. 423:152-157(2012) [PubMed] [Europe PMC] [Abstract]

"Chemerin: a potential endocrine link between obesity and type 2 diabetes."
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"Towards an integrative approach to understanding the role of chemerin in human health and disease."
Obes. Rev. 14:245-262(2013) [PubMed] [Europe PMC] [Abstract]

"Chemerin is an antimicrobial agent in human epidermis."
PLoS ONE 8:E58709-E58709(2013) [PubMed] [Europe PMC] [Abstract]