Signal Regulatory Protein Beta 1 (SIRPb1)

CD172-B; CD172b; SIRP-B1; SIRP-beta-1; CD172 antigen-like family member B

SPN	V862
HGNC	15928
MGI	2444824
PubMed	19893026
UniProt	O00241
Wiki	SIRPB1

Signal-regulatory protein beta 1 is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene. The signal regulatory protein-beta1 (SIRPbeta1) is a DAP12-associated transmembrane receptor expressed in a subset of hematopoietic cells. Recently, it was shown that peritoneal macrophages express SIRPbeta1, which positively regulated phagocytosis.

Reference

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Nature 386:181-186(1997) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Association of signal-regulatory proteins beta with KARAP/DAP-12."
Eur. J. Immunol. 30:2147-2156(2000) [PubMed] [Europe PMC] [Abstract]

"Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells."
J. Immunol. 164:9-12(2000) [PubMed] [Europe PMC] [Abstract]

"SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration."
J. Biol. Chem. 280:36132-36140(2005) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the first Ig-like domain of signal-regulatory protein beta-1 (SIRP-beta-1)."
Submitted (DEC-2006) to the PDB data bank