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Signal Regulatory Protein Alpha (SIRPa)

CD172a; SIRP-A; P84; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; Macrophage fusion receptor

Signal-regulatory protein alpha is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Hu01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Hu01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Hu01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Hu01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Hu01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Mu01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Mu01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Mu01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Mu01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Mu01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Ra01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Ra01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Ra01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Ra01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Ra01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Ca01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Ca01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Ca01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Ca01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Ca01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Po01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Po01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Po01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Po01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Po01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Bo01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Bo01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Bo01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Bo01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Bo01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Rb01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Rb01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Rb01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Rb01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Rb01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV858Mo01 Recombinant Signal Regulatory Protein Alpha (SIRPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV858Mo01 Monoclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IP.
PAV858Mo01 Polyclonal Antibody to Signal Regulatory Protein Alpha (SIRPa) WB; IHC; ICC; IF.
Assay Kits CLV858Mo01 CLIA Kit for Signal Regulatory Protein Alpha (SIRPa) CLIA assay for Antigen Detection
ELV858Mo01 ELISA Kit for Signal Regulatory Protein Alpha (SIRPa) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes."
Biochem. Biophys. Res. Commun. 231:61-67(1997) [PubMed] [Europe PMC] [Abstract]

"A family of proteins that inhibit signalling through tyrosine kinase receptors."
Nature 386:181-186(1997) [PubMed] [Europe PMC] [Abstract]

"Gene structure of mouse BIT/SHPS-1."
Biochem. J. 344:667-675(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells."
Eur. J. Immunol. 28:1-11(1998) [PubMed] [Europe PMC] [Abstract]

"SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages."
Curr. Biol. 9:927-930(1999) [PubMed] [Europe PMC] [Abstract]

"Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha."
J. Biol. Chem. 275:28222-28229(2000) [PubMed] [Europe PMC] [Abstract]

"Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation."
J. Immunol. 167:2547-2554(2001) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors."
J. Biol. Chem. 282:14567-14575(2007) [PubMed] [Europe PMC] [Abstract]

"Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]