Activin A Receptor Type I (ACVR1)
ACVR1A; ALK2; ACVRLK2; TSRI; FOP; SKR1; ACTRI; Activin receptor-like kinase 2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I
Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Hu01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Hu01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Hu01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Hu01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Hu01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Mu01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Mu01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Mu01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Mu01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Mu01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Ra01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Ra01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Ra01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Ra01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Ra01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Ca01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Ca01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Ca01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Ca01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Ca01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Po01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Po01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Po01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Po01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Po01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Bo01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Bo01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Bo01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Bo01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Bo01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Rb01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Rb01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Rb01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Rb01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Rb01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV843Mo01 | Recombinant Activin A Receptor Type I (ACVR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV843Mo01 | Monoclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IP. |
| PAV843Mo01 | Polyclonal Antibody to Activin A Receptor Type I (ACVR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV843Mo01 | CLIA Kit for Activin A Receptor Type I (ACVR1) | CLIA assay for Antigen Detection |
| ELV843Mo01 | ELISA Kit for Activin A Receptor Type I (ACVR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor."
J. Biol. Chem. 268:12719-12723(1993) [PubMed] [Europe PMC] [Abstract]
"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
Oncogene 8:2879-2887(1993) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin."
Submitted (JUN-2009) to the PDB data bank
"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva."
Nat. Genet. 38:525-527(2006) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
"Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1."
Hum. Mutat. 30:379-390(2009) [PubMed] [Europe PMC] [Abstract]
"Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients."
PLoS ONE 4:E5005-E5005(2009) [PubMed] [Europe PMC] [Abstract]