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Cyclophilin A (CYPA)

PPIA; CyP-A; CYPH; Peptidylprolyl Isomerase A; Peptidyl-Prolyl Isomerase A; Peptidyl-prolyl cis-trans isomerase A; Cyclosporin A-binding protein

Cyclophilin A, also called Peptidyl-prolyl Isomerase A, PPIA, CYPA, and CYPH, was originally characterized for its ability to catalyze the transition between cis- and trans- proline residues critical for proper folding of proteins. Cyclophilin is also incorporated into many viruses, including HIV-1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin, making it a useful inhibitor for studying calcineurin activity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V833Hu01 Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies MV833Hu21 Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
PV833Hu01 Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
LV833Hu71 Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits KEV833Hu ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V833Mu01 Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
PV833Mu01 Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
LV833Mu81 FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits KEV833Mu ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V833Ra01 Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies MV833Ra21 Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
PV833Ra01 Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
LV833Ra71 Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
LV833Ra81 FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits KEV833Ra ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V833Po01 Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
PV833Po01 Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V833Bo01 Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
PV833Bo01 Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
LV833Bo71 Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins V833Si01 Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
PV833Si01 Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclophilin A (CYPA) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclophilin A (CYPA) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclophilin A (CYPA) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclophilin A (CYPA) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclophilin A (CYPA) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclophilin A (CYPA) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclophilin A (CYPA) CLIA assay for Antigen Detection

Reference

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EMBO J. 6:947-950(1987) [PubMed] [Europe PMC] [Abstract]

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"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
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, Submitted (DEC-2008) to UniProtKB

, Submitted (NOV-2005) to UniProtKB

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"Initial characterization of the human central proteome."
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"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
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"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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"Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy."
Nature 353:276-279(1991) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of recombinant human T-cell cyclophilin A at 2.5-A resolution."
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"X-ray structure of a decameric cyclophilin-cyclosporin crystal complex."
Nature 361:91-94(1993) [PubMed] [Europe PMC] [Abstract]

"X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1-A resolution."
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"Crystal structure implies that cyclophilin predominantly catalyzes the trans to cis isomerization."
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"Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein."
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"X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A."
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"Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes."
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"Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin."
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"Solution structure of the cyclosporin A/cyclophilin complex by NMR."
Nature 361:88-91(1993) [PubMed] [Europe PMC] [Abstract]

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