Protein Tyrosine Phosphatase Receptor Type H (PTPRH)

PTPR-H; SAP1; Stomach cancer-associated protein tyrosine phosphatase 1; Transmembrane-type protein-tyrosine phosphatase type H

SPN	V828
HGNC	9672
MGI	3026877
PubMed	15850787
UniProt	Q9HD43
Wiki	PTPRH

Receptor-type tyrosine-protein phosphatase H is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.

Reference

"Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers."
J. Biol. Chem. 269:2075-2081(1994) [PubMed] [Europe PMC] [Abstract]

"Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome."
Cytogenet. Cell Genet. 92:213-216(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas."
J. Biol. Chem. 276:15216-15224(2001) [PubMed] [Europe PMC] [Abstract]

"Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1."
J. Biol. Chem. 277:34359-34366(2002) [PubMed] [Europe PMC] [Abstract]

"Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function."
J. Biol. Chem. 278:34854-34863(2003) [PubMed] [Europe PMC] [Abstract]

"Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma."
Oncogene 22:4656-4663(2003) [PubMed] [Europe PMC] [Abstract]

"Sap-1/PTPRH activity is regulated by reversible dimerization."
Biochem. Biophys. Res. Commun. 331:497-502(2005) [PubMed] [Europe PMC] [Abstract]