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Glypican 4 (GPC4)

K-Glypican; Glypican Proteoglycan 4; Secreted glypican-4

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.The deduced 556-amino acid GPC4 protein is 93.5% identical to mouse K-glypican. Northern blot analysis detected 2 GPC4 transcripts of 2.9 kb and 4.3 kb in most human fetal and adult tissues tested.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Hu01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Hu01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Hu01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Hu01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Hu01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Mu01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Mu01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Mu01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Mu01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Mu01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Ra01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Ra01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Ra01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Ra01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Ra01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Ca01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Ca01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Ca01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Ca01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Ca01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Po01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Po01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Po01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Po01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Po01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Bo01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Bo01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Bo01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Bo01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Bo01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Rb01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Rb01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Rb01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Rb01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Rb01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV814Mo01 Recombinant Glypican 4 (GPC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV814Mo01 Monoclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IP.
PAV814Mo01 Polyclonal Antibody to Glypican 4 (GPC4) WB; IHC; ICC; IF.
Assay Kits CLV814Mo01 CLIA Kit for Glypican 4 (GPC4) CLIA assay for Antigen Detection
ELV814Mo01 ELISA Kit for Glypican 4 (GPC4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"GPC4, the gene for human K-glypican, flanks GPC3 on Xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome."
Genomics 53:1-11(1998) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."
Hum. Mol. Genet. 9:1321-1328(2000) [PubMed] [Europe PMC] [Abstract]