Glycoprotein Ib Beta Polypeptide, Platelet (GP1Bb)

CD42c;CD42-c; GP1-BB; GPIB-B

SPN	V796
HGNC	4440
MGI	107852
PubMed	21800012
RGD	621050
UniProt	P13224
Wiki	GP1BB

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes.

Reference

"The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence."
Proc. Natl. Acad. Sci. U.S.A. 85:2135-2139(1988) [PubMed] [Europe PMC] [Abstract]

"Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta."
J. Biol. Chem. 269:17424-17427(1994) [PubMed] [Europe PMC] [Abstract]

"Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22."
J. Clin. Invest. 93:2417-2424(1994) [PubMed] [Europe PMC] [Abstract]

"Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence."
J. Clin. Invest. 99:520-525(1997) [PubMed] [Europe PMC] [Abstract]

"Missense mutations of the glycoprotein (GP) Ib beta gene impairing the GPIb alpha/beta disulfide linkage in a family with giant platelet disorder."
Blood 89:2404-2412(1997) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the alpha and beta chains of human platelet glycoprotein Ib."
Biochem. Biophys. Res. Commun. 147:526-534(1987) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"Platelet glycoprotein Ib beta is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase."
J. Biol. Chem. 264:15656-15661(1989) [PubMed] [Europe PMC] [Abstract]

"Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet."
Blood 109:603-609(2007) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbbeta and a GPIbbeta/GPIX chimera."
Blood 118:5292-5301(2011) [PubMed] [Europe PMC] [Abstract]