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Alpha-2-Macroglobulin (a2M)

A2MG; A2mg; CPAMD5; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

Alpha2-macroglobulin is a major serum protein with diverse functions, including inhibition of protease activity and binding of growth factors, cytokines, and disease factors. It is also a panproteinase inhibitor that is found immunohistochemically in neuritic plaques.

Alpha-2-macroglobulin is able to inactivate an enormous variety of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). Alpha-2-macroglobulin has in its structure a 35 aminoacid "bait" region. Proteinases binding and cleaving the bait region become bound to alpha2M. The proteinase-α2M complex is recognised by macrophage receptors and cleared from the system.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Hu01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Hu01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Hu01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Hu01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Hu01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Mu01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Mu01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Mu01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Mu01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Mu01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Ra01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Ra01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Ra01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Ra01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Ra01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Ca01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Ca01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Ca01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Ca01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Ca01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Po01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Po01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Po01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Po01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Po01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Bo01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Bo01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Bo01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Bo01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Bo01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Rb01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Rb01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Rb01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Rb01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Rb01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV795Mo01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV795Mo01 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAV795Mo01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CLV795Mo01 CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA assay for Antigen Detection
ELV795Mo01 ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus."
Proc. Natl. Acad. Sci. U.S.A. 82:2282-2286(1985) [PubMed] [Europe PMC] [Abstract]

"Alpha(2) macroglobulin, a PSA-binding protein, is expressed in human prostate stroma."
Prostate 63:299-308(2005) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the human alpha-2 macroglobulin gene and its promotor."
Biochem. Biophys. Res. Commun. 184:596-603(1992) [PubMed] [Europe PMC] [Abstract]

"Primary structure of human alpha 2-macroglobulin. V. The complete structure."
J. Biol. Chem. 259:8318-8327(1984) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Biol. Chem. 260:6500-6500(1985)

"Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit."
J. Biol. Chem. 261:15863-15869(1986) [PubMed] [Europe PMC] [Abstract]

"A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin."
FEBS Lett. 262:349-352(1990) [PubMed] [Europe PMC] [Abstract]

"Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site."
Hum. Genet. 88:313-319(1992) [PubMed] [Europe PMC] [Abstract]

"Human alpha 2-macroglobulin gene is located on chromosome 12."
Somat. Cell Mol. Genet. 11:285-289(1985) [PubMed] [Europe PMC] [Abstract]

"Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase."
Biochem. Biophys. Res. Commun. 100:8-16(1981) [PubMed] [Europe PMC] [Abstract]

"Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex."
FEBS Lett. 127:167-173(1981) [PubMed] [Europe PMC] [Abstract]

"Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin."
FEBS Lett. 135:295-300(1981) [PubMed] [Europe PMC] [Abstract]

"Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region."
Hoppe-Seyler's Z. Physiol. Chem. 364:1297-1302(1983) [PubMed] [Europe PMC] [Abstract]

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin."
Protein Sci. 7:2602-2612(1998) [PubMed] [Europe PMC] [Abstract]

"Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3."
Biochem. J. 407:23-30(2007) [PubMed] [Europe PMC] [Abstract]

"Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene."
Nucleic Acids Res. 19:198-198(1991) [PubMed] [Europe PMC] [Abstract]