Angiopoietin Like Protein 4 (ANGPTL4)
ARP4; FIAF; HFARP; NL2; PGAR; Pp1158; Fasting-Induced Adipose Factor; Hepatic Angiopoietin-Related Protein; Hepatic Fibrinogen/Angiopoietin-Related Protein
Angiopoietin-related protein 4 is a a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Hu01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Hu01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Hu01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Hu01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Hu01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Mu01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Mu01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Mu01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Mu01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Mu01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Ra01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Ra01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Ra01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Ra01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Ra01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Ca01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Ca01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Ca01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Ca01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Ca01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Po01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Po01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Po01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Po01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Po01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Bo01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Bo01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Bo01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Bo01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Bo01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Rb01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Rb01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Rb01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Rb01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Rb01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV793Mo01 | Recombinant Angiopoietin Like Protein 4 (ANGPTL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV793Mo01 | Monoclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IP. |
| PAV793Mo01 | Polyclonal Antibody to Angiopoietin Like Protein 4 (ANGPTL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV793Mo01 | CLIA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | CLIA assay for Antigen Detection |
| ELV793Mo01 | ELISA Kit for Angiopoietin Like Protein 4 (ANGPTL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis."
Biochem. J. 346:603-610(2000) [PubMed] [Europe PMC] [Abstract]
"Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation."
Mol. Cell. Biol. 20:5343-5349(2000) [PubMed] [Europe PMC] [Abstract]
"Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis."
Zhonghua Yi Xue Za Zhi 82:94-99(2002) [PubMed] [Europe PMC] [Abstract]
"Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4."
Cancer Res. 63:6651-6657(2003) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Expression and function of hepatocellular carcinoma-related gene pp1158."
Zhonghua Zhong Liu Za Zhi 24:123-125(2002) [PubMed] [Europe PMC] [Abstract]
"Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL."
Nat. Genet. 39:513-516(2007) [PubMed] [Europe PMC] [Abstract]