Ubiquitin Activating Enzyme E1 Like Protein (UBE1L)
UBE1-L; D8; UBE2; UBA7; Ubiquitin Like Modifier Activating Enzyme 7
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family.
Ubiquitin-like modifier-activating enzyme 7 is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Hu01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Hu01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Hu01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Hu01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Hu01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Mu01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Mu01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Mu01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Mu01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Mu01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Ra01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Ra01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Ra01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Ra01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Ra01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Ca01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Ca01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Ca01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Ca01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Ca01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Po01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Po01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Po01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Po01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Po01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Bo01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Bo01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Bo01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Bo01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Bo01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Rb01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Rb01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Rb01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Rb01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Rb01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV785Mo01 | Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV785Mo01 | Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IP. |
| PAV785Mo01 | Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV785Mo01 | CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | CLIA assay for Antigen Detection |
| ELV785Mo01 | ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme."
Proc. Natl. Acad. Sci. U.S.A. 90:6071-6075(1993) [PubMed] [Europe PMC] [Abstract]
"The genomic structure of the human UBE1L gene."
Gene Expr. 4:163-175(1995) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
"Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein."
EMBO J. 20:362-371(2001) [PubMed] [Europe PMC] [Abstract]
"Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo."
J. Virol. 79:13974-13983(2005) [PubMed] [Europe PMC] [Abstract]
"ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells."
Proc. Natl. Acad. Sci. U.S.A. 107:2253-2258(2010) [PubMed] [Europe PMC] [Abstract]
"Covalent protein modification with ISG15 via a conserved cysteine in the hinge region."
PLoS ONE 7:E38294-E38294(2012) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]