Albumin (ALB)
Serum albumin
Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in the ALB gene on chromosome 4 result in various anomalous proteins.Albumin is a globular unglycosylated serum protein of molecular weight 65,000. The albumin variant first described by Fraser et al. in a Welsh family was characterized as a dimer by Jamieson and Ganguly. The amino acid sequence has been determined in fragments of serum albumin of man. By 1980, at least 2 dozen electrophoretic variants of serum albumin had been reported but only 2 of them had been characterized with respect to their primary structure: albumin A and albumin B.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Hu01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Hu01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Hu01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Hu01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Hu01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Mu01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Mu01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Mu01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Mu01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Mu01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Ra01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Ra01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Ra01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Ra01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Ra01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Ca01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Ca01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Ca01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Ca01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Ca01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Po01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Po01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Po01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Po01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Po01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Bo01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Bo01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Bo01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Bo01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Bo01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Rb01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Rb01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Rb01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Rb01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Rb01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV784Mo01 | Recombinant Albumin (ALB) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV784Mo01 | Monoclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IP. |
PAV784Mo01 | Polyclonal Antibody to Albumin (ALB) | WB; IHC; ICC; IF. | |
Assay Kits | CLV784Mo01 | CLIA Kit for Albumin (ALB) | CLIA assay for Antigen Detection |
ELV784Mo01 | ELISA Kit for Albumin (ALB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The sequence of human serum albumin cDNA and its expression in E. coli."
Nucleic Acids Res. 9:6103-6114(1981) [PubMed] [Europe PMC] [Abstract]
"Nucleotide sequence and the encoded amino acids of human serum albumin mRNA."
Proc. Natl. Acad. Sci. U.S.A. 79:71-75(1982) [PubMed] [Europe PMC] [Abstract]
"Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4."
J. Biol. Chem. 261:6747-6757(1986) [PubMed] [Europe PMC] [Abstract]
"Induction of galactose regulated gene expression in yeast."
Patent number EP0248637, 09-DEC-1987
"Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."
Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The human albumin gene. Characterization of the 5' and 3' flanking regions and the polymorphic gene transcripts."
J. Biol. Chem. 261:3244-3251(1986) [PubMed] [Europe PMC] [Abstract]
"Complete amino acid sequence of human serum albumin."
FEBS Lett. 58:134-137(1975) [PubMed] [Europe PMC] [Abstract]
(In) Bing D.H. (eds.);The chemistry and physiology of the human plasma proteins, pp.23-40, Pergamon Press, New York (1979)
"The human myocardial two-dimensional gel protein database: update 1994."
Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
, Submitted (DEC-2008) to UniProtKB
"The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin."
Biochem. Biophys. Res. Commun. 136:983-988(1986) [PubMed] [Europe PMC] [Abstract]
"Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s)."
J. Biol. Chem. 262:5968-5973(1987) [PubMed] [Europe PMC] [Abstract]
"Lysine residue 199 of human serum albumin is modified by acetylsalicylic acid."
FEBS Lett. 66:173-175(1976) [PubMed] [Europe PMC] [Abstract]
"Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides."
J. Am. Soc. Mass Spectrom. 15:496-509(2004) [PubMed] [Europe PMC] [Abstract]
"Disulfide bonds in human serum albumin."
Collect. Czech. Chem. Commun. 42:564-579(1977)
"Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin."
Biochem. J. 171:453-459(1978) [PubMed] [Europe PMC] [Abstract]
"The principal site of nonenzymatic glycosylation of human serum albumin in vivo."
J. Biol. Chem. 258:6142-6146(1983) [PubMed] [Europe PMC] [Abstract]
"Nonenzymatic glycosylation of human serum albumin alters its conformation and function."
J. Biol. Chem. 259:3812-3817(1984) [PubMed] [Europe PMC] [Abstract]
"Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites."
J. Biol. Chem. 261:13542-13545(1986) [PubMed] [Europe PMC] [Abstract]
"A nucleotide insertion and frameshift cause analbuminemia in an Italian family."
Proc. Natl. Acad. Sci. U.S.A. 91:2275-2279(1994) [PubMed] [Europe PMC] [Abstract]
"Albumin as a zinc carrier: properties of its high-affinity zinc-binding site."
Biochem. Soc. Trans. 36:1317-1321(2008) [PubMed] [Europe PMC] [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Three-dimensional structure of human serum albumin."
Science 244:1195-1198(1989) [PubMed] [Europe PMC] [Abstract]
"Structure of human serum albumin."
Science 249:302-303(1990) [PubMed] [Europe PMC] [Abstract]
"Atomic structure and chemistry of human serum albumin."
Nature 358:209-215(1992) [PubMed] [Europe PMC] [Abstract]
Erratum
Nature 364:362-362(1993)
"Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites."
Nat. Struct. Biol. 5:827-835(1998) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human serum albumin at 2.5-A resolution."
Protein Eng. 12:439-446(1999) [PubMed] [Europe PMC] [Abstract]
"Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures."
J. Biol. Chem. 275:38731-38738(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids."
J. Mol. Biol. 314:955-960(2001) [PubMed] [Europe PMC] [Abstract]
"Albumin Canterbury (313 Lys-->Asn). A point mutation in the second domain of serum albumin."
Biochim. Biophys. Acta 912:191-197(1987) [PubMed] [Europe PMC] [Abstract]
"Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning."
Proc. Natl. Acad. Sci. U.S.A. 84:4413-4417(1987) [PubMed] [Europe PMC] [Abstract]
"Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations."
Proc. Natl. Acad. Sci. U.S.A. 84:8001-8005(1987) [PubMed] [Europe PMC] [Abstract]
"Identical structural changes in inherited albumin variants from different populations."
Proc. Natl. Acad. Sci. U.S.A. 86:434-438(1989) [PubMed] [Europe PMC] [Abstract]
"Point substitutions in Japanese alloalbumins."
Proc. Natl. Acad. Sci. U.S.A. 86:6092-6096(1989) [PubMed] [Europe PMC] [Abstract]
"Point substitutions in albumin genetic variants from Asia."
Proc. Natl. Acad. Sci. U.S.A. 87:497-501(1990) [PubMed] [Europe PMC] [Abstract]
"Albumin Redhill (-1 Arg, 320 Ala-->Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site."
Proc. Natl. Acad. Sci. U.S.A. 87:26-30(1990) [PubMed] [Europe PMC] [Abstract]
"Mutations in genetic variants of human serum albumin found in Italy."
Proc. Natl. Acad. Sci. U.S.A. 87:8721-8725(1990) [PubMed] [Europe PMC] [Abstract]
"A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin."
Proc. Natl. Acad. Sci. U.S.A. 88:5959-5963(1991) [PubMed] [Europe PMC] [Abstract]
"Genetic variants of serum albumin in Americans and Japanese."
Proc. Natl. Acad. Sci. U.S.A. 88:9853-9857(1991) [PubMed] [Europe PMC] [Abstract]
"Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp-->Asn)."
Biochim. Biophys. Acta 1097:49-54(1991) [PubMed] [Europe PMC] [Abstract]
"Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions."
Biochim. Biophys. Acta 1119:232-238(1992) [PubMed] [Europe PMC] [Abstract]
"Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants."
Proc. Natl. Acad. Sci. U.S.A. 89:8225-8229(1992) [PubMed] [Europe PMC] [Abstract]
"The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240-->Glu] albumin mutant."
Eur. J. Biochem. 214:437-444(1993) [PubMed] [Europe PMC] [Abstract]
"Albumin Hawkes Bay; a low level variant caused by loss of a sulphydryl group at position 177."
Biochim. Biophys. Acta 1182:46-50(1993) [PubMed] [Europe PMC] [Abstract]
"Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys)."
Biochim. Biophys. Acta 1225:27-32(1993) [PubMed] [Europe PMC] [Abstract]
"Genetic variants of human serum albumin in Italy: point mutants and a carboxyl-terminal variant."
Proc. Natl. Acad. Sci. U.S.A. 91:6476-6480(1994) [PubMed] [Europe PMC] [Abstract]
"An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families."
Biochem. Biophys. Res. Commun. 202:781-787(1994) [PubMed] [Europe PMC] [Abstract]
"Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia."
J. Clin. Endocrinol. Metab. 80:461-467(1995) [PubMed] [Europe PMC] [Abstract]
"A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred."
J. Clin. Endocrinol. Metab. 82:3246-3250(1997) [PubMed] [Europe PMC] [Abstract]
"Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect."
J. Clin. Endocrinol. Metab. 83:1448-1454(1998) [PubMed] [Europe PMC] [Abstract]
"Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry I. Profiling an unfractionated tryptic digest."
Proteomics 1:93-107(2001) [PubMed] [Europe PMC] [Abstract]
"A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges."
Eur. J. Biochem. 268:344-352(2001) [PubMed] [Europe PMC] [Abstract]