Protein Tyrosine Phosphatase Receptor Type C (PTPRC)

CD45; PTPR-C; LCA; B220; GP180; LY5; T200; Leukocyte common antigen

SPN	V782
HGNC	9666
MGI	97810
PubMed	11528386
RGD	3451
UniProt	P08575
Wiki	PTPRC

PTPRC is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP.

PTPRC is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.

Reference

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