Surfactant Associated Protein D (SPD)

SFTPD; COLEC7; PSP-D; SFTP4; SP-D; Pulmonary Surfactant Protein D; Collectin-7; Lung surfactant protein D

SPN	V773
HGNC	10803
MGI	109515
PubMed	16684127
RGD	3667
UniProt	P35247
Wiki	SP-D

Surfactant protein D (SP-D) belongs to the collectin family.These proteins are oligomeric proteins composed of carbohydrate-recognition domains(CRD)attached to collagenous regions.Collectins are structurally similar to the ficolins although they make use of different CRD structures:C-type lectin domain for the collectins.The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type Ⅱcells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointestinal tract and in epithelial cells of various exocrine glands. SP-D is an important factor in the pulmonary anti-microbial defense. The anti-microbial defense mechanisms of SP-D are direct opsonization, neutralization and agglutination.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	V773Hu01	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	MV773Hu22	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	PV773Hu01	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	LV773Hu71	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	KEV773Hu	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	V773Mu01	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	PV773Mu01	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	KEV773Mu	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	V773Ra01	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	MV773Ra21	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	PV773Ra01	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	LV773Ra81	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	KEV773Ra	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Surfactant Associated Protein D (SPD)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Surfactant Associated Protein D (SPD)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Surfactant Associated Protein D (SPD)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Surfactant Associated Protein D (SPD)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Surfactant Associated Protein D (SPD)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Surfactant Associated Protein D (SPD)	CLIA assay for Antigen Detection

Reference

"Purification, characterization and cDNA cloning of human lung surfactant protein D."
Biochem. J. 284:795-802(1992) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1."
J. Biol. Chem. 268:2976-2983(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Accumulation of surfactant protein D in human pulmonary alveolar proteinosis."
Am. J. Pathol. 142:241-248(1993) [PubMed] [Europe PMC] [Abstract]

"Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain."
Arch. Biochem. Biophys. 290:116-126(1991) [PubMed] [Europe PMC] [Abstract]

"The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status."
Int. J. Obes. Relat. Metab. Disord. 37:1532-1538(2013) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D."
Structure 7:255-264(1999) [PubMed] [Europe PMC] [Abstract]

"Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]