Integrin Beta 1 (ITGb1)

CD29; MSK12; ITG-B1; FNRB; GPIIA; MDF2; MSK12; VLAB; Fibronectin Receptor Beta Polypeptide; Antigen CD29 Includes MDF2; Glycoprotein IIa; VLA-4 subunit beta

SPN	V770
HGNC	6153
MGI	96610
PubMed	23441154
RGD	2927
UniProt	P05556
Wiki	CD29

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), also known as ITGB1 or CD29, is a human gene. CD29 is an integrin unit associated with very late antigen receptors. Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.

Reference

"Amino acid sequence of the human fibronectin receptor."
J. Cell Biol. 105:1183-1190(1987) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit."
J. Cell Biol. 121:171-178(1993) [PubMed] [Europe PMC] [Abstract]

"Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility."
J. Cell Biol. 127:557-565(1994) [PubMed] [Europe PMC] [Abstract]

"A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing."
Gene 95:261-266(1990) [PubMed] [Europe PMC] [Abstract]

"An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain."
J. Biol. Chem. 267:7116-7120(1992) [PubMed] [Europe PMC] [Abstract]

"Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle."
Biochem. Biophys. Res. Commun. 214:279-285(1995) [PubMed] [Europe PMC] [Abstract]

"A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle."
FEBS Lett. 369:340-344(1995) [PubMed] [Europe PMC] [Abstract]

"Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C."
Biochem. J. 330:1255-1263(1998) [PubMed] [Europe PMC] [Abstract]

"Interaction of ACE2 and integrin beta1 in failing human heart."
Biochim. Biophys. Acta 1689:175-178(2004) [PubMed] [Europe PMC] [Abstract]

"Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2."
J. Virol. 67:6847-6852(1993) [PubMed] [Europe PMC] [Abstract]

"Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells."
J. Cell Biol. 132:211-226(1996) [PubMed] [Europe PMC] [Abstract]

"Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin."
EMBO J. 17:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]

"The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."
Blood 94:663-672(1999) [PubMed] [Europe PMC] [Abstract]

"A novel protease-docking function of integrin at invadopodia."
J. Biol. Chem. 274:24947-24952(1999) [PubMed] [Europe PMC] [Abstract]

"A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation."
J. Cell Biol. 147:1391-1398(1999) [PubMed] [Europe PMC] [Abstract]

"Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation."
Hum. Mol. Genet. 10:2953-2960(2001) [PubMed] [Europe PMC] [Abstract]

"Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement."
J. Biol. Chem. 277:20895-20902(2002) [PubMed] [Europe PMC] [Abstract]

"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]

"The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading."
J. Cell Biol. 156:377-387(2002) [PubMed] [Europe PMC] [Abstract]

"Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha."
J. Biol. Chem. 278:6567-6574(2003) [PubMed] [Europe PMC] [Abstract]

"RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1."
J. Biol. Chem. 279:13027-13034(2004) [PubMed] [Europe PMC] [Abstract]

"NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]

"Myosin-X provides a motor-based link between integrins and the cytoskeleton."
Nat. Cell Biol. 6:523-531(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration."
Dev. Cell 9:663-673(2005) [PubMed] [Europe PMC] [Abstract]

"The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."
J. Cell Sci. 118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]

"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]

"Interaction of integrin beta1 with cytokeratin 1 in neuroblastoma NMB7 cells."
Biochem. Soc. Trans. 35:1292-1294(2007) [PubMed] [Europe PMC] [Abstract]

"Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments."
Dev. Cell 13:496-510(2007) [PubMed] [Europe PMC] [Abstract]

"Integrin trafficking regulated by Rab21 is necessary for cytokinesis."
Dev. Cell 15:371-385(2008) [PubMed] [Europe PMC] [Abstract]

"JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation."
J. Cell Biol. 183:1159-1173(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry."
J. Virol. 84:10026-10037(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration."
J. Biol. Chem. 286:43735-43747(2011) [PubMed] [Europe PMC] [Abstract]

"Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."
J. Cell Biol. 194:307-322(2011) [PubMed] [Europe PMC] [Abstract]

"Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins."
J. Cell Sci. 124:879-891(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Mechanistic insights into regulated cargo binding by ACAP1 protein."
J. Biol. Chem. 287:28675-28685(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor."
J. Cell Biol. 197:131-140(2012) [PubMed] [Europe PMC] [Abstract]

"Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation."
Mol. Cell 49:719-729(2013) [PubMed] [Europe PMC] [Abstract]